Protective effect of propofol preconditioning and postconditioning against ischemic spinal cord injury  

作　　者：Qijing Yu Ji Hu Jie Yang Shuzhou Yin 

机构地区：[1]Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China [2]Department of Anesthesiology, Liyuan Hospital of Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430077, Hubei Province, China [3]Department of Anesthesiology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou 215021, Jiangsu Province, China

出　　处：《Neural Regeneration Research》2011年第12期951-955,共5页中国神经再生研究（英文版）

基　　金：the Natural Science Foundation of Hubei Province,No.2009CDB130;Fundamental Research Funds for the Central Universities (HUST),No.M2009049

摘　　要：Propofol preconditioning has been shown to provide neuroprotection against spinal ischemia/reperfusion injury. In this study, spinal cord ischemia/repeffusion injury was induced by blocking the abdominal aorta in rabbits for 40 minutes. Results showed that the co-application of propofol preconditioning and postconditioning regimen ameliorated pathological injury of the ischemic spinal cord and suppressed the elevation of malondialdehyde levels and increased superoxide dismutase activities in the spinal cord tissues. Co-application of propofol preconditioning and postconditioning resulted in potent protective effects against spinal cord ischemia/reperfusion injury and prolonged the spinal cord＇s tolerance to ischemia. This protection was associated with the anti-lipid peroxidation capacity of the spinal cord tissues.Propofol preconditioning has been shown to provide neuroprotection against spinal ischemia/reperfusion injury. In this study, spinal cord ischemia/repeffusion injury was induced by blocking the abdominal aorta in rabbits for 40 minutes. Results showed that the co-application of propofol preconditioning and postconditioning regimen ameliorated pathological injury of the ischemic spinal cord and suppressed the elevation of malondialdehyde levels and increased superoxide dismutase activities in the spinal cord tissues. Co-application of propofol preconditioning and postconditioning resulted in potent protective effects against spinal cord ischemia/reperfusion injury and prolonged the spinal cord＇s tolerance to ischemia. This protection was associated with the anti-lipid peroxidation capacity of the spinal cord tissues.

关 键 词：ischemia/reperfusion injury spinal cord PROPOFOL ANTIOXIDATION neural regeneration 

分 类 号：Q463[生物学—生理学] Q257