直肠癌组织Smac与Survivin表达及其临床意义的探讨  

Expressions and clinical significance of Smac and Survivin in rectal cancer tissues

作　　者：孙红芹[1] 赵长林[1] 胡芳娟[1] 张甘露[1] 张超[1] 杨扬[1] 

机构地区：[1]大连大学附属新华医院肿瘤科,辽宁大连116021

出　　处：《中华肿瘤防治杂志》2011年第12期956-960,共5页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨Smac和Survivin蛋白在直肠癌组织中的表达及临床意义。方法:应用免疫组织化学技术检测Smac和Survivin蛋白在60例直肠癌组织、30例直肠腺瘤组织及10例癌旁正常黏膜组织中的表达。结果:Smac在直肠癌组织、直肠腺瘤及癌旁正常组织的表达率分别为71.67%(43/60)、96.67%(29/30)和100.00%(10/10),差异有统计学意义,χ2=13.981,P=0.001。Sur-vivin在直肠癌组织、直肠腺瘤及癌旁正常组织的表达率分别为90.00%(54/60)、80.00%(24/30)和20.00%(2/10),差异有统计学意义,χ2=9.539,P=0.002。Smac和Survivin蛋白的表达水平与患者的年龄、性别、肿瘤部位、术前CEA水平、肿瘤分化程度和远处转移无关(P值均>0.05),但与TNM分期和淋巴结转移有关,P值均<0.05。Smac阳性率与淋巴结转移呈负相关,r=-0.079,P<0.05;Survivin阳性率与淋巴结转移呈正相关,r=0.236,P<0.05。Smac和Survivin在直肠癌中的表达呈负相关,r=-0.086,P<0.05。结论:Smac和Survivin蛋白表达与直肠癌的病理分期和淋巴结转移密切相关,Smac在直肠癌中低表达,其表达与Survivin呈负相关,两者在直肠癌细胞凋亡信号传导网络中可能发挥重要的作用。中华肿瘤防治杂志,2011,18(12)OBJECTIVE： To detecte the expressions and clinical significance of Smac and Survivin in rectal carcinoma, and further explore its clinical value. METHODS： The expression levels of Smac and Survivin were detected in 60 cases with rectal carcinoma, 30 cases with rectal adenoma and 10 cases with normal paraneoplastic rectal mucosae tissues using immunohistochemistry. RESULTS： The positive expression rate of Smac in rectal carcino ma tissues,rectal adenoma,normal tissues were 71.67%（43/60）, 96. 67%（29/30）, 100.00% （10/10）. The rates had significant difference（x^2=13. 981, P=0. 001）. The positive expression rate of Survivin in rectal carcinoma tissues, rectal adenoma, normal tissues were 90.0% （54/60）, 80.0% （24/30）, 20.00% （2/10）. The rates had significant difference（3（2 = 9. 539, P= 0. 002）. Posi tive expression of Smac and Survivin had no relationship with patient＇s age, gender, tumor location, CEA, differentiation, and distant metastasis respectively （P 〉 0.05）, but had difference in TNM staging, lymph node metastasis respectively （P 〈 0.05 ）. The expression of Smac had negative correlation with the lymph node metastasis （ r = -0.079, P% 0.05）. The expression of Survivin had positive correlation with the lymph node metastasis（r--0. 236, P%0.05）. The expression of Smac and Survivin had significant nega- tive correlation in rectal carcinoma （r = -0. 086, P 〈 0.05 ）. CONCLUSIONS： Smac and Survivin expression were closely related with the pathological stage of rectal carcinoma, lymph node metastasis. Smac was a negative correlation with Survivin and two genes may be an important link in the signal pathway of rectal carcinoma.

关 键 词：直肠肿瘤 SMAC蛋白 SURVIVIN蛋白 免疫组织化学 

分 类 号：R735.37[医药卫生—肿瘤]