非酒精性脂肪性肝病在2型糖尿病患者中的患病率及其危险因素研究  

Frequency and Risk Factors of Nonalcoholic Fatty Liver Disease among Type 2 Diabetic Patients

作　　者：高建勤[1] 张晶[1] 季宇[1] 胡逢来[1] 杨婧[1] 

机构地区：[1]北京航天总医院内分泌科,北京市100076

出　　处：《中国全科医学》2011年第20期2236-2238,共3页Chinese General Practice

基　　金：北京市首都医学发展科研基金(2007-1035)

摘　　要：目的了解非酒精性脂肪性肝病(NAFLD)在2型糖尿病(T2DM)患者中的患病率,并分析其危险因素。方法选取312例T2DM患者为研究对象,检测所有对象的肝肾功能、血糖、胰岛素、血脂等生化指标,并计算胰岛素抵抗指数(HOMA-IR)。由超声诊断NAFLD。结果T2DM患者中NAFLD患病率为47.0%(147/312)。T2DM伴NAFLD组患者的腰围、体质量、体质指数(BMI)均显著高于单纯T2DM组,差异有统计学意义(P<0.01)。T2DM伴NAFLD组患者空腹胰岛素、三酰甘油水平、HOMA-IR、尿微量清蛋白(MALB)、合并代谢综合征的比例均显著高于单纯NAFLD组,差异有统计学意义(P<0.05)。结论NAFLD在T2DM患者中患病率高,超重、腹型肥胖、高三酰甘油血症、高胰岛素血症是其发生的危险因素。Objective To investigate the frequency and risk factors of non-alcoholic fatty liver disease（NAFLD） in patients with type 2 diabetes mellitus.Methods Blood samples of 312 patients were collected for assessment of glycemic and lipid profiles,liver enzymes,and HOMA-IR.The diagnosis of NAFLD was established by ultrasound.Results NAFLD was diagnosed in 47.0% of patients with higher waist circumference,body weight,and BMI（P0.01）.The levels of triglycerides,insulin,and HOMA-IR were significantly higher in T2DM patients with NAFLD than those without NAFLD（P0.05）.Conclusion lmost half of the patients with T2DM were found to have NAFLD.They showed elevated BMI,higher levels of triglycerides,insulin,and HOMA-IR compared with those without NAFLD.

关 键 词：糖尿病 2型 非酒精性脂肪性肝病 胰岛素抵抗 危险因素 

分 类 号：R575[医药卫生—消化系统]