非酒精性脂肪性肝病与凝血及纤溶系统异常的关系  

Correlations between Nonalcoholic Fatty Liver Disease and Abnormality of the Coagulation and Fibrinolysis System

作　　者：于轶楠[1] 都健[1] 

机构地区：[1]中国医科大学附属第一医院内分泌科,辽宁省沈阳市110001

出　　处：《中国全科医学》2011年第20期2239-2241,共3页Chinese General Practice

基　　金：辽宁省科学技术计划项目(2009225029);辽宁省教育厅科学技术研究项目(L2010597)

摘　　要：随着生活水平的提高、非酒精性脂肪性肝病(NAFLD)领域研究的迅速发展及许多新的、有价值的临床循证依据不断报道,发现NAFLD与代谢紊乱相关疾病的共患人群增多,并对NAFLD的关注也从它本身的肝病意义扩展到代谢意义。目前NAFLD的发病机制尚不清楚,都还停留在假说阶段,其中占主导地位的观点是"二次打击假说",即"第一次打击"是胰岛素抵抗,"第二次打击"是氧化应激。本文从NAFLD发病机制的角度,阐述了NAFLD与凝血及纤溶系统异常的关系。With the enhancement of living standards,rapid progress has been made concerning the field of nonalcoholic fatty liver disease（NAFLD）,with many new and valuable clinical evidences being reported.It has been noted that population with comorbidity of link NAFLD and metabolic disorders has enlarged,and more and more attention has been paid to the metabolic significance of the disease rather than the disease itself.Mechanisms for NAFLD pathogenesis are still not clear.Up until now,the dominant idea is the ＂two-hit hypothesis＂,namely ＂the first hit＂ refers to insulin resistance,and ＂the second hit＂ refers to oxidative stress.This article describes the correlations between nonalcoholic fatty liver disease and abnormality of the coagulation and fibrinolysis system from the aspect of pathogenesis.

关 键 词：非酒精性脂肪性肝病 胰岛素抵抗 氧化性应激 血液凝固 纤溶系统 

分 类 号：R575[医药卫生—消化系统]