SnailmRNA在乳腺癌中的表达及临床意义  

Expression and Clinical Significance of Snail mRNA in Breast Cancer

作　　者：熊正文[1] 李永申[1] 李伟[1] 李宏伟[1] 黄勇[1] 张华东[1] 寻凤华[1] 

机构地区：[1]中国人民解放军二五一医院病理科,北京军区肿瘤病理技术研究诊疗中心,河北省张家口市075000

出　　处：《中国全科医学》2011年第21期2408-2410,2413,共4页Chinese General Practice

基　　金：全军医学科学技术研究“十一五”计划课题(06MB085)

摘　　要：目的观察Snail mRNA在人乳腺癌组织中的表达及其与临床病理特征的关系,并探讨其在乳腺癌发生、发展中的作用及临床应用价值。方法应用原位分子杂交方法,检测Snail mRNA在70例乳腺癌、30例乳腺导管内癌和30例乳腺单纯性增生组织中的表达。结果 70例乳腺癌组织中Snail mRNA阳性率为81.4%(57/70),分别高于乳腺导管内癌组织的阳性率46.7%(14/30)和乳腺单纯性增生组织的阳性率23.3%(7/30),三者比较差异有统计学意义(χ2=32.4,P<0.01)。有淋巴结转移者Snail mRN阳性率为92.7%(38/41),无转移者阳性率为65.5%(19/29),两者比较差异有统计学意义(χ2=8.29,P<0.01);Snail mRNA的表达与年龄、肿瘤大小及组织学分级均无关(P>0.05)。结论 Snail mRNA的表达与乳腺癌的发生、发展及淋巴结转移密切相关,可作为判断乳腺癌预后、转移的生物学标志。Objective To observe the expression of Snail mRNA in breast cancer and the relationship between Snail mRNA and clinicopathological features and to investigate its roles in the carcinogenesis and progression of breast cancer and its clinical application value.Methods The expression of Snail mRNA was detected by in situ hybridization（ISH） in breast carcinoma（70 cases）,intraductal breast carcinoma（30 cases） and simplex breast hyperplasia（30 cases）.Results Among the 70 cases of breast cancer,the expression rate of Snail mRNA was 81.4%,higher than the expression rate in intraductal breast carcinoma（46.7%） and simplex breast hyperplasia（23.3%）,the difference was statistically significant（χ2=32.4,P0.01）.The expression rate of Snail mRNA in lymphatic metastasis group was 92.7%,but 65.5% in no lymphatic metatasis group,and there was statistically significant difference between the two groups（χ2=8.29,P0.01）.Snail mRNA expression was not correlated to age,tumor size and histopathological grade（P0.05）.Conclusion The expression of Snail mRNA is closely related to the occurrence and development of breast carcinoma and lymphatic metastasis,and is thought as prognostic and metastatic biology markers of breast cancer.

关 键 词：SNAIL 乳腺癌 原位分子杂交 上皮-间质转化 

分 类 号：R737.9[医药卫生—肿瘤]