安徽省育龄妇女多囊卵巢综合征患病状况流行病学研究  

Characteristics of polycystic ovary syndrome in women of reproductive age in Anhui province

作　　者：刘迎春[1] 魏兆莲[1] 徐玉萍[1] 吴娟[1] 许孝凤[1] 周平[1] 曹云霞[1] 

机构地区：[1]安徽医科大学第一附属医院生殖医学中心,合肥230022

出　　处：《生殖医学杂志》2011年第3期178-182,共5页Journal of Reproductive Medicine

基　　金：国家"十一五"科技支撑计划课题(2007BAI04B04)

摘　　要：目的了解安徽省育龄妇女多囊卵巢综合征(PCOS)的患病状况、临床特点及危险因素。方法以2003年鹿特丹PCOS诊断标准,按照临床流行病学多阶段分层随机抽样方法,抽取1,024名育龄妇女进行调查。结果安徽省育龄妇女PCOS群体患病率为5.4%;检出的PCOS患者中月经稀发、高雄激素血症和卵巢多囊样改变(PCO)分别占90.9%、63.6%、72.7%,月经稀发为最主要临床表现;PCOS人群月经不规则、多毛、痤疮、皮肤油腻/溢脂、PCO、不育症的发生率显著高于非PCOS人群(P≤0.01),PCOS组的血清睾酮、雄烯二酮和游离睾酮指数均显著高于非PCOS组(P<0.05);不同特征育龄妇女PCOS发病率比较,初潮后建立规则月经周期时间延长、母亲不育与育龄妇女PCOS相关性有显著统计学意义(P<0.05)。结论安徽省育龄妇女PCOS的群体患病率为5.4%;PCOS妇女不育症的发生率为10.9%;月经稀发可作为PCOS的首先筛选指标,初潮后建立规则月经周期延长及母亲不育可能是PCOS的危险因素。Objective： To explore the clinic and epidemiologic characteristics of polycystic ovary syndrome （PCOS） in women of reproductive age in Anhui province. Methods： A total of 1,024 Anhui women of reproductive age were chosen according to ter sampling design. The prevalence, medical features and lab test results of PCOS in the tion were analyzed. a stratified clus sampled popula Results： The prevalence of PCOS in these sampled women was 5.4%. The oligomenorrhea was the most common clinical manifestation in women with PCOS （90. 9%）, followed by polycystic ovary （72.7%）, hyperandrogenism （63.6%） and infertility （10.9G）. The incidences of irregular menstruation, hyperandrogenism symptoms, polycystic ovary and infertility were all higher in women with PCOS than those without PCOS （P≤0. 01）. Women with PCOS also had higher serum levels of testosterone and androstenedione and a higher free androgen index （P〈0.05）. The longer time of establishing regular men- strual cycles after menarehe and a history of motherrs infertility were significantly correlated with PCOS （P〈0.05）. Conclusions： The prevalence of PCOS in the sampled women of reproductive age in Anhui province was 5.4%. Oligomenorrhea might serve as the first simple indicator for scanning of PCOS in the women of reproductive age. The longer time to establish regular menstrual cycles after menarche and a history of mother＇s infertility might be the risk factors of PCOS.

关 键 词：多囊卵巢综合征 流行病学 高雄激素血症 

分 类 号：R[医药卫生]