缩宫素对超声消融治疗子宫肌瘤效果的影响  

Effect of oxytocin on uterine fibroids treated by ultrasound ablation

作　　者：黄秀[1] 何敏[1] 刘映江[1] 张炼[1] 王智彪[1] 

机构地区：[1]重庆医科大学生物医学工程学院,400016

出　　处：《中华妇产科杂志》2011年第6期412-415,共4页Chinese Journal of Obstetrics and Gynecology

基　　金：国家重点基础研究发展计划（2011CB707902）;国家科技支撑计划（2006BA103A02）

摘　　要：目的探讨缩宫素对超声消融治疗子宫肌瘤效果的影响。方法采用MRI引导下的超声消融肿瘤治疗系统，以单点辐照的方式，选择确诊的26例子宫肌瘤患者的29个肌瘤中的82个靶点进行研究，比较使用缩宫素前、后辐照单点达到60℃时所需的能量、时间及升高单位温度（1℃）所需的能量。结果使用缩宫素前，辐照单点温度达到60qC所需的能量为（5320±910）J，时间为（21±20）s，升高1℃所需的能量为（255±302）J；静脉滴注缩宫素后，辐照单点温度达到60℃所需的能量为（2890±325）J，时间为（12±7）s，升高1℃所需的能量为（126±94）J。使用缩宫素前、后，各指标问比较，差异均有统计学意义（P值分别为0．002、0．001、0．002）。结论缩宫素能明显降低超声消融治疗子宫肌瘤所需的能量，缩短治疗时间，从而提高治疗效率，具有很好的临床应用价值。Objective To explore the effect of oxytocin on uterine fibroids treated by ultrasound ablation. Methods Eighty-two single points in 29 uterine fibroids from 26 patients were sonicated with magnetic resonance imaging guided by high intensity focused ultrasound before and after using oxytocin. The required total energy, sonication time required to reach 60 ℃and the acoustic energy for increasing 1℃ of temperature at the single point before and after using oxytocin were compared. Results Before intravenous infusion of oxytocin, the average total sonication energy required to reach 60 ℃ was （5320 ±910） J and it took （21 ±20） seconds for sonicating a single point, the energy required for increasing 1 ℃was （255 ± 302） J. In contrast, after intravenous infusion of oxytocin, the average total sonication energy required to reach 60 ℃was （2890 ±325 ） J, and it took （ 12 ±7 ） seconds for sonicating a single point, the energy required for increasing 1℃was （ 126 ± 94 ） J. Those three index all reached statistical difference （ P = 0. 002, P = 0. 001, P = 0. 002, respectively）. Conclusion It seemed that Oxytocin could significantly decrease the energy required for ablating uterine fibroids, shorten treatment time and improve the treatment efficiency.

关 键 词：子宫肿瘤 平滑肌瘤 超声疗法 导管消融术 催产素 磁共振成像 

分 类 号：R737.33[医药卫生—肿瘤]