ghrelin与功能性消化不良  

Ghrelin and functional dyspepsia

作　　者：蔡顺天[1,2] 王巍峰[1] 杨云生[1,2] 

机构地区：[1]解放军总医院消化科,北京100853 [2]南开大学医学院

出　　处：《胃肠病学和肝病学杂志》2011年第6期579-582,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：功能性消化不良(FD)患者尽管未发现胃肠道器质性病变,但是研究提示FD可能存在胃动力、胃排空、胃十二指肠神经调节或内脏敏感性等胃肠道功能的改变。ghrelin作为主要由胃X/A样细胞产生的一种多肽,影响胃的动力、排空和分泌功能。最近的研究表明血清中的ghrelin水平与FD有一定的关系,提示其可能在FD的发病机制中起一定的作用,值得深入的研究。Though there are no evidences of organic change in patients with functional dyspepsia （FD） , abnormalities of gastric emptying, dysregulation of gastroduodenal motility, and visceral hypersensitivity are often present in FD. Ghrelin is one kind of brain-gut peptide mainly secreted by gastric X/A-like cell. As it affects gastric motility, emptying and secretion, this peptide may play a pathophysiological role in FD. Recently, plasma ghrelin level is reported to be altered in FD, which indicates further investigations are needed.

关 键 词：GHRELIN 功能性消化不良 餐后不适综合征 上腹部疼痛综合征 

分 类 号：R57[医药卫生—消化系统]