胃癌患者髓过氧化物酶基因多态性分析  

Analysis for myeloperoxidase genetic polymorphism in gastric cancer

作　　者：王黔[1] 严芝强[1] 王海斌[1] 谢海涛[1] 于扬[1] 

机构地区：[1]贵阳医学院附属医院胃肠外科,550004

出　　处：《中华胃肠外科杂志》2011年第7期542-544,共3页Chinese Journal of Gastrointestinal Surgery

摘　　要：目的探讨髓过氧化物酶（MPO）基因多态性与胃癌发病的关系。方法按照病例对照研究的方法，收集62例胃癌患者和61名健康对照者外周血标本．提取DNA进行MPO-463位点基因多态性检测。结果MPO．463GG、GA和AA3种基因型的频率在胃癌组中分别为87．1％、11．3％和1．6％，在对照组中分别为72．1％、23．0％和4．9％；将携带MPO-463GA和AA型者合并后与携带MPO-463GG型相比较，患胃癌的风险显著增高（P=0．039，OR=0．383，95％CI：0．151-0．972）。相对于G等位基因，携带A等位基因的个体患胃癌的风险显著降低（P=0．026，OR=0．399，95％CI：0．174～0．916）。结论MPO-463G／A多态性与胃癌的发生有关．其中A基因是一个保护基因。Objective To investigate the association of myeloperoxidase （MPO） genetic polymorphism and gastric cancer. Methods A case-control study was performed including 62 patients with gastric cancer and 61 healthy controls. Peripheral blood was collected for genetic analysis of MPO- 463. Results There were no significant differences in gender, age, and smoking between the two groups （P〉0.05）. However, the two groups differed in drinking, family history of gastric cancer, and Helicobacter pylori（HP） infection（P〈0.05）. The frequencies of MPO-463GG, GA and AA were 87.1%, 11.3% and 1.6%in the study group, and were 72.1%, 23.0%, and 4.9% in the control group, respectively. Carriers of MPO-463 GA or AA had a significantly higher risk of gastric cancer than those of MPO-463 GG （Х^2=4.253, P〈0.05, 0R=0.383, 95% CI：0.151-0.972）. Carriers of G allele had a significantly lower risk of gastric cancer compared to carriers of A allele （Х^2=4.935,P〈0.05, OR=0.399,95%CI：0.174-0.916）. Conclusion MPO-463 G/A polymorphism is associated with gastric cancer with A being a protective gene.

关 键 词：胃肿瘤 髓过氧化物酶 基因多态性 

分 类 号：R735.2[医药卫生—肿瘤]