大鼠脑桥、中脑电损伤后脑干听觉诱发电位的敏感性研究  

Investigation of sensitive indexes of BAEP in rats exposed to electric injury in pones and midbrains

作　　者：朱沂[1] 包国庆[1] 孙娟[1] 党辉[1] 李建新[1] 孙振柱[1] 

机构地区：[1]新疆维吾尔自治区人民医院神经外科,乌鲁木齐830001

出　　处：《中华神经外科杂志》2011年第6期671-675,共5页Chinese Journal of Neurosurgery

基　　金：国家自然科学基金（81060104）;新疆维吾尔自治区自然科学基金（2010211A56）

摘　　要：目的 探讨大鼠脑桥、中脑电损伤后脑干听觉诱发电位（BAEP）的敏感指标。方法SD大鼠80只，分别于左侧脑桥面丘和中脑上下丘之间深部给予电损伤，按照电流刺激量的不同各分为小剂量组（1mA）、中剂量组（3mA）、高剂量组（6xnA）、对照组（0mA），每组10只，记录和比较各组电损伤前后的BAEP各指标的变化。每组取2只行病理学检查。结果电损伤后，脑组织均有不同程度的神经元坏死等改变，损伤程度随电流量加大而增加。脑桥小剂量组BAEP的V波的PL、Ⅲ～Ⅴ、Ⅰ～Ⅴ波IPL延长，中剂量组的Ⅲ、Ⅴ波的PL、Ⅰ～Ⅲ、Ⅲ～Ⅴ、Ⅰ～Ⅴ波IPL延长，高剂量组的Ⅲ、V波的PL、Ⅰ-Ⅲ、Ⅲ～Ⅴ、Ⅰ～Ⅴ波IPL延长，伴Ⅲ、Ⅴ波的波幅下降；中脑中剂量组、高剂量组V波PL延长，Ⅰ—Ⅴ、Ⅲ～V波IPL延长，损伤前后的差值与对照组比较，有统计学意义。结论（1）BAEP的V波PL可能为反映脑桥和中脑损伤的敏感指标；（2）BAEP反映中脑损伤不如脑桥敏感。Objective To explore the sensitive indexes of brainstem auditory evoked potentials （BAEP） in rats exposed to electric injury in the pans and the midbrains. Methods The pones and midbrains of 80 rats were electric injured beneath the left facial colliculus and quadrigeminal bodies. In the pone group or the midbrain group, the animals were further divided into 4 groups： controls （0mA）, low （ 1mA）, middle （3mA） and high electric current （6mA） respectively, according to the amount of electrical stimulation. The indexes of BAEP were recorded and analyzed before and after injury. Results It was shown that electric injury resulted in neuronal necrosis, the extent of which tended to be designated as much more severe according to the amount of electrical stimulation. In the pone groups, the peak lantency （PL） of waves V and the interpeak lantency （IPL） of waves Ⅰ - Ⅴ, Ⅲ-Ⅴ were prolonged at low electric current. However, the PL of waves Ⅲ, V and the IPL of waves Ⅰ-Ⅲ, Ⅲ-Ⅴ, Ⅰ - Ⅴ were prolonged at middle and high electric current, and the amplitudes of waves V were decreased at high electric current significantly compared with the controls. In the midbrain groups, the PL of waves Vand the IPL of waves Ⅲ - Ⅴ, Ⅰ - Ⅴ at middle and high electric current were prolonged significantly compared with the controls. Conclusions The peak lantency of the waves V may be the most sensitive indexes of BAEP as to the pons and midbrains injured, but the changes of BAEP is less sensitive in midbrain than in pons.

关 键 词：脑干听觉诱发电位 术中神经电生理监护 

分 类 号：R741[医药卫生—神经病学与精神病学]