STK15基因单核苷酸多态性与结直肠癌风险的Meta分析  

Relationship between STK15Phe31Ile polymorphism and risk of colorectal cancer:a Meta-analysis

作　　者：杨燊[1] 段生宇 钟荣[2] 刘丽[2] 刘莉[2] 聂绍发[2] 缪小平[2] 

机构地区：[1]北京大学人民医院普通外科,北京100034 [2]华中科技大学同济医学院公共卫生学院流行病与卫生统计学系,湖北武汉430030

出　　处：《基础医学与临床》2011年第8期909-913,共5页Basic and Clinical Medicine

摘　　要：目的综合评估STK15基因单核苷酸多态性与结直肠癌易感性的关系。方法以"STK15"、"polymorphism"、"aurora-A"、"colorectal cancer"、"colorectal carcinoma"、"结直肠癌"、"STK15基因"和"基因多态性"等为主题词检索Pubmed、EMbase、SCI、Web of Science、CNKI、VIP、万方等中英文数据库,并未进行语种限制。对所获文献进行质量评价、筛选和异质性检验,要求所纳入文献均为非相关的病例对照研究,并以OR值为效应指标,基因型在对照群体中的分布均符合Hardy-Weinberg遗传平衡定律。利用Stata10.0软件进行Meta分析。结果共纳入6篇研究文献,累计病例5 158例,对照4 608例,Phe/Ile和Ile/Ile基因型同Phe/Phe基因型相比较,OR值及其95%可信区间分别为1.01(95%CI:0.93～1.10)和1.18(95%CI:0.98～1.42);对应的P值分别为0.81和0.081。结论 STK15Phe31Ile基因单核苷酸多态性与结直肠癌的发病风险无关,中国人群中STK15 Phe31Ile多态性与结直肠癌易感性关系需要进一步的研究证实。Objective To determine whether STK15 Phe31Ile polymorphism contributes to genetic susceptibility to colorectal cancer.MethodsPubmed,EMbase,SCI,Web of Science,CNKI,VIP and some other databases were searched for literatures published from January 2000 to April 2010.Articles were identified using the Medical Subject Headings term ＂STK15＂,＂polymorphism＂,＂aurora-A＂,＂colorectal cancer＂,＂colorectal carcinoma＂.Case control studies involving unrelated subjects and genotype frequencies in control group consistent with Hardy-Weinberg equilibrium were included.The software Stata（version10.0） was used for Meta-analysis.Results Six studies including 5 158 patients and 4 608 controls met the selection criteria.The combined OR of susceptibility to colorectal cancer with Phe/Ile and Ile/Ile compared to Phe/Phe were 1.01（95% CI： 0.93～1.10） and 1.18（95% CI： 0.98～ 1.42）;and their responding P values were 0.81 and 0.081 respectively.Conclusions The findings suggest STK15 Phe31Ile polymorphism is not correlated with susceptibility to colorectal cancer.

关 键 词：STK15 基因多态性 结直肠癌 META-分析 易感性 

分 类 号：R735.3[医药卫生—肿瘤]