维奥欣对非酒精性脂肪肝血脂及氧化应激的影响研究  

Weiaoxin Affect Non-alcoholic Fatty Liver Lipids and Oxidative Stress Research

作　　者：张朕华[1] 张中则[1] 李泽仁[1] 

机构地区：[1]上海交通大学医学院,上海200240

出　　处：《中国医药指南》2011年第20期219-220,共2页Guide of China Medicine

摘　　要：目的评价维奥欣(薯蓣皂苷)对非酒精性脂肪肝血脂及氧化应激的影响。方法 316非酒精性,按照随机数字表的方式随机治疗组165例给予基础治疗+薯蓣皂苷片,对照组151例给予基础治疗+安慰剂,疗程10周。检测两组患者服药前后空腹血糖(FPG)、血清胰岛素(FIns)、三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白(LDL-c)、氧化应激指标,同时计算计算胰岛素敏感指数(ISI)。结果治疗组治疗后血TG、TC、LDL-c较对照组及治疗前显著降低(P<0.01),氧化应激指标及胰岛素敏感指数(ISI)显著改善(P<0.05)。结论薯蓣皂苷片能显著调节慢性非酒精性脂肪肝血脂水平,改善胰岛素抵抗、减轻氧化应激。治疗期间仅个别病例有轻微上腹不适,安全性较好。Objective To evaluate the efficacy and safety of diosgenin tablet for the alcoholic fatty liver associated with hyperlipemia and oxidatie stress. Methods 316 patients were divided into treatment group and control group randomly by random number table. Treatment group was given to fundamental therapy plus diosgenin tablet, while control group was only treated with fundamental therapy for 8 weeks. Index of blood Lipid, FBG, Fins, hemarheology and oxidatie stress were detected before and after treatment in 8 weeks. Results TG, TG, LDL-c were lower markedly in treatment group after treatment; insulin sensitive index and oxidatie stress were improved significantly too after treatment, when comparing with control group. Conclusions Clinical research indicates that diosgenin tablet can regulate blood lipid notably, it also can improve insulin sensitive index and oxidatie stress. There were only several patients having epigastric discomfort during treatment therapeutic process.

关 键 词：薯蓣皂苷片 非酒精性脂肪肝 血脂 氧化应激 

分 类 号：R575[医药卫生—消化系统]