Bcl-w基因在胃癌中的表达和临床病理因素的关系  

Expression of Bcl-w in gastric carcinoma and associated clinicopathologic factors

作　　者：郝占伟[1] 姜德清[1] 夏春咸[1] 

机构地区：[1]连云港市第二人民医院普外科,连云港222000

出　　处：《国际外科学杂志》2011年第7期458-461,F0003,共5页International Journal of Surgery

摘　　要：目的探讨B细胞淋巴因子-w（Bcl—w）在胃癌中的表达与预后的关系。方法通过免疫组化SP法，检测100例胃癌组织中Bcl—w和MMP-2（基质金属蛋白-2）的表达。结果（1）100例胃癌中Bcl-w和MMP-2表达的阳性率分别为69．0％、77．0％；（2）胃癌组织中Bcl-w和MMP-2的表达与肿瘤的大小、浸润深度、组织分化程度和淋巴结转移正相关（P〈0．05）；（3）胃癌组织中Bcl—w表达与MMP-2表达显著相关（P=0．002）；（4）Bcl—w阳性患者5年生存率和总体生存率低于Bcl-w阴性患者。结论（1）Bcl—W在抑制胃癌细胞凋亡、促进胃癌侵袭转移中发挥重要的作用；（2）Bcl-w在胃癌中的表达与预后负相关，可作为胃癌预后的评价指标。Objective To discuss the meaning and association with prognosis of Bcl-w expression in gastric carcinoma. Methods By Immunohistochemistry（SP）method was used to detect the expression of Bcl-w and MMP-2 in 100 cases of human gastric carcinoma. Results （ 1 ） Among 100 cases of stomach carcinoma, Bcl-w and MMP-2 positive expression rates were respectively 69.0%, 77.0%;（2）The Bcl-w and MMP-2 expression in gastric carcinoma was positively associated with tumor size, invasive depth, histology differentiation and lymph node metastasis（ P 〈 0.05 ） ; （ 3 ） The expression of Bcl-w was significantly correlated with MMP- 2 in gastric carcinomas （ P = 0. 002） ; （4） Five years survival rates and overall survival of Bcl- w-positive patients were lower than the Bcl-w -negative patients. Conclusions （ 1 ） Bcl-w plays an important role in inhibiting apoptosis of gastric cancer and promoting gastric cancer invasion;（ 2 ）Bcl-w-positive expression patients have a bad prognosis and Bcl-w expression in gastric carcinoma can be regarded as a prognosis evaluation index.

关 键 词：胃肿瘤 Bcl—w 基质金属蛋白-2 预后 

分 类 号：R735.2[医药卫生—肿瘤]