长期干预颈内动脉系统短暂性脑缺血发作患者HHCY的观察  

Effect of Long-Term Homocysteine Reduction with B Vitamins on risk of recurrent ischemic cerebral vascular events by following up in transient ischemic attacks patients

作　　者：王建生[1] 金梅芳[1] 

机构地区：[1]常熟市第一人民医院神经内科,湖北常熟215500

出　　处：《医药论坛杂志》2011年第9期16-17,20,共3页Journal of Medical Forum

摘　　要：目的探讨长期干预高同型半胱氨酸血症(Hhcy)与颈内动脉系统短暂性脑缺血发作(TIA)预后与转归的相关性,为TIA的治疗与预防提供参考。方法收集伴有Hhcy的颈内动脉系统TIA患者,随机分为治疗组105例和对照组78例,对照组给予常规治疗;治疗组在常规治疗基础上加用叶酸片及维生素B6、维生素B12片(甲钴胺),随访2年后缺血性脑血管事件发生情况;比较治疗前后Hcy水平,评价TIA患者的再发性脑血管事件发生率及药物不良反应发生率。结果 2年后对照组空腹Hcy水平与常规治疗前相比无显著差异,治疗组空腹血浆Hcy水平降低,与治疗前比较有显著差异,治疗组的缺血性脑血管事件复发率与对照组相比无显著差异。结论口服叶酸加维生素B6、B12可降低高同型半胱氨酸血症,且干预Hhcy有减少TIA后再发缺血性脑血管事件的趋势。Objective To determine whether vitamin supplements（folic acid 2 mg,B（6） 25mg,B（12） 500 mg） reduce the risk of recurrent ischemic cerebral vascular events by following up in transient ischemic attacks（TIA） patients and its safety.Methods Totally 183 patients with hyperhomocysteinemia（Hhcy） and internal carotid artery system TIA were divided into therapy group（105 patients） and control group（78 patients） at random.The free plasma homocysteine（Hcy） was measured and the addition of B-vitamin supplements（folic acid 2 mg,B（6） 25 mg,B（12） 500 mg/d） to therapy group was recorded.Within a two-year follow-up period,the recurrence of ischemic cerebral vascular events and the safety were observed.Results The free plasma Hcy concentration was significantly reduced in therapy group after two years.There was no statistical significance of the recurrence of ischemic cerebral vascular events between two groups.Conclusions We provide the effectiveness and the safety of that B-vitamin supplements which can decrease plasma Hcy levels.Long term treatment homocysteine reduction with B Vitamins may be effective to the tendency of recurrence of ischemic cerebral vascular events in TIA patients with hyperhomocysteinemia

关 键 词：高同型半胱氨酸血症 TIA 治疗 再发 

分 类 号：R743.31[医药卫生—神经病学与精神病学]