华法令预防非瓣膜性房颤患者并发脑梗塞的疗效观察  

Effect of Warfarin on nonvalvular atrial fibrillation complicated with cerebral embolism

作　　者：刘富良[1] 蒋彬[1] 

机构地区：[1]重庆市江津区第二人民医院,重庆江津402289

出　　处：《海南医学院学报》2011年第8期1051-1053,共3页Journal of Hainan Medical University

基　　金：海南医学院科研基金资助学报项目(0020110265)~~

摘　　要：目的:观察华法令预防非瓣膜性房颤患者并发脑梗塞的疗效。方法:选取我院2006年1月～2009年12月收治的非瓣膜性房颤患者204例,随机分为两组,分别应用华法令和肠溶阿司匹林对其治疗,治疗时间为6个月,分析比较两组患者脑卒中及不良反应的发生率。结果:观察组86例,发生脑梗塞3例(3/86,3.5%),对照组118例,发生脑梗塞16例(16/118,13.6%),两组比较差异有统计学意义(P<0.05);观察组发生不良反应23例(23/86,26.7%),对照组发生不良反应35例(35/118,29.7%),两组比较差异无统计学意义(P>0.05)。结论:非瓣膜性房颤患者应用华法令能显著降低脑梗塞的发生率,但应注意个体差异化用药,降低不良反应的发生率。Objective：To observe effect of Wrfarin nonvalvular atrial fibrillation （NVAF） comp;icated with cerebral embolism.Method：A total of 204 patients with NVAF admitted From January 2006 to Dccember 2009,Were selected,and were randomly divided into two groups.Patients in control group were treated by aspirin,while patients in observation group were treated with Warfarin for 6 months.The incidence of cerebral infarction and side effect were observed and compared.Results：Out of 86 cases in observation group,3 cases of NVAF suffered cerebral infarction,accounting for 3.5%;while in control group,16 cases of NVAF suffered cerebral infarction,accounting for 13.6%;there was significant difference between two groups （P〈0.05）.In observation group,23 had side effect （26.7）,while 16 cases in control group had side effect （29.7%） of the total;there was no significant difference（P〉0.05）.Conclusions：Wararin can prevent cerebral infarction effectively in NVAF patients.It is necessary to pay attention on individuation medication,which can decrease the incidence of side effect.

关 键 词：非瓣膜性房颤 脑梗塞 华法令 肠溶阿司匹林 

分 类 号：R74[医药卫生—神经病学与精神病学]