茯苓三萜成分及其衍生物的构效关系研究  

Studies on the Derivatives and Structure Activity Relationships of Fuling Triterpene

作　　者：沈芊[1] 许先栋[1] 顾慧儿[1] 

机构地区：[1]中国医学科学院中国协和医科大学医药生物技术研究所,北京100050

出　　处：《中国药物化学杂志》1999年第4期271-276,共6页Chinese Journal of Medicinal Chemistry

摘　　要：从国产茯苓中分离出3 种茯苓三萜成分,制备了14 个茯苓三萜衍生物,其化学结构经元素分析、质谱、红外、紫外和核磁共振等确证无误.同时测定了它们对小鼠肝癌H22 细胞的抑制率,并对其构效关系进行了初步推断.In search of antitumor structure activity relationships of fuling triterpene and its derivatives and looking for more effective antitumor compounds,we designed and prepared fourteen derivatives of fuling triterpene in this paper.The structures of these new compounds were examined by IR,UV,Mass and 1H NMR spectra as well as elemental analysis.Results of antitumor activity to tumor cell H 22 showed∶The antitumor activity of the ester derivatives was increased,but antitumor activity of the ester derivatives had Cl and Br decreased.

关 键 词：茯苓三萜 三萜衍生物 抗肝癌 构效关系 

分 类 号：R284.1[医药卫生—中药学] R273.57[医药卫生—中医学]