海洋生物毒素检测的动物试验替代方法及标准化  

Alternative methods for testing marine biotoxin in animal models and the standardization of these methods

作　　者：程树军 焦红 谈伟君[2] 

机构地区：[1]广东出入境检验检疫技术中心食品实验室,广东广州510623 [2]广东药学院食品科学学院,广东广州510310

出　　处：《中国食品卫生杂志》2011年第4期373-377,共5页Chinese Journal of Food Hygiene

基　　金：广东省科技计划项目(2009B060300013)

摘　　要：海洋生物毒素结构多样、种类繁多、作用机制复杂,给人类健康带来潜在的风险。使用动物模型检测贝类组织中的海洋毒素是许多国家监控计划推荐的方法。近年来,新的基于毒性作用机制和明确化学结构的检测方法不断被开发,如细胞检测法、免疫学方法、化学分析法和生物传感器方法等。有的方法已进入标准化和验证程序,逐渐被认可用于监控和检测目的 。Marine biotoxins bring potential health risks to human.Because of the complexity of chemical structure and the diversity of action mechanism of marine biotoxin,monitoring programs in many countries use animal models to detect the presence of marine biotoxin in shellfish tissues.Many new assay methods based on the mechanism and definite chemical structure of marine biotoxin were developed in recent years,including functional,immunological,chemical methods and biosensors.Several methods are going on the way of validation and standardization,and are gradually accepted by regulations.

关 键 词：海洋生物毒素 动物实验 替代方法 标准化 食品安全 

分 类 号：R114[医药卫生—卫生毒理学]