淋巴管生成因子在头颈肿瘤淋巴结转移中的作用  

Lymphangiogenesis factor in the lymph node metastasis of head and neck cancer

作　　者：孙树军[1] 赵立民[1] 周建明[1] 

机构地区：[1]潍坊医学院附属医院耳鼻咽喉科,261030

出　　处：《国际肿瘤学杂志》2011年第7期509-512,共4页Journal of International Oncology

摘　　要：头颈肿瘤早期出现淋巴结转移是常见的临床现象，寻找和发现阻断肿瘤淋巴结转移的方法和途径对恶性肿瘤的治疗起到至关重要的作用。现在淋巴管生成过程中得以证实的信号传导分子机制是血管内皮生长因子（VEGF）-C和VEGF—D，这两种分子蛋白通过结合激活淋巴管内皮细胞表面的血管内皮生长因子受体-3（VEGFR-3）发挥作用，但确切的分子机制还存在许多争议。Early lymph node metastasis is a common clinical phenomenon in many human cancers, which is associated with both aggressive disease and poor prognosis. Clearly, treatments to specifically block dissemination through the lymphatic network would be desirable either as independent therapies or as adjuncts to existing chemotherapy. At the present stage the target vessels for invasion by lymph-metastasizing tumor cells include preexisting tissue lymphatics abutting the tumor mass through either coincidence or mutual chemoattraction, as well as new lymphatic vessels that proliferate either within or around the tumor as a result of lymphangiogenesis. The lymphangiogenesis is regulated primarily by the lymphangiogenic growth factors VEGF-C and VEGF-D generated by tumor cells or host cells including tissue macrophages. Nevertheless, it remains controversial as to whether this metastasis-enhancing effect simply results from an increase of the number of target vessels due to mitogenesis or from other properties of the newly dividing tumor lymphatics.

关 键 词：淋巴转移 血管内皮生长因子类 头颈部肿瘤 

分 类 号：R739.91[医药卫生—肿瘤]