肾细胞癌的微卫星不稳定性研究  

Microsatellite Instability in Renal Cell Carcinoma

作　　者：唐东起[1] 俞莉章[1] 丁义[1] 刘漓波[1] 郭应禄[1] 

机构地区：[1]北京医科大学泌尿外科研究所,100034

出　　处：《中国医师杂志》1999年第12期10-12,共3页Journal of Chinese Physician

摘　　要：为探讨微卫星不稳定性在肾细胞癌的发生发展中的作用及其与临床病理指标的关系，建立了以ＰＣＲ 为基础的微卫星分析方法，选择分布在不同染色体上的１５ 个微卫星位点，共检测３４ 例新鲜肿瘤标本。３４ 例中有１５ 例（４４－１ ％ ）表现为微卫星不稳定性，并多见于晚期肿瘤（Ⅲ－ Ⅳ期）。结果提示微卫星不稳定性较广泛地存在于肾细胞癌中，可能与肿瘤发展有关。To demonstrate whether microsatellite instability(MSI) is involved in the development of renal cell carcinoma and its relations to the clinicopathologic parameters,on the basis of PCR technique,a microsatellite instability assay was established.By the method,we detected 15 microsatellite loci localized on different chromosome in the thirty-four fresh frozen specimens.Microsatellite instabilities were recognized in 15 out of 34(44 1%) tumor specimens examined and were extensively existed in advanced cancer (stage Ⅲ-Ⅳ).No relation was found between microsatellite instability and other clinicopathologic factors.Our results indicate that microsatellite instability was importantly involved in human renal cell carcinoma and it might be associated with the development of the disaese.

关 键 词：微卫星不稳定性 肾细胞癌 肿瘤发展 病理学 

分 类 号：R737.110.2[医药卫生—肿瘤]