下方自体角膜缘干细胞移植术治疗翼状胬肉的疗效分析  

The analysis of the bottom limbal stem cell autograft transplantation in the treatment of pterygium

作　　者：王瑛[1] 邓妮妮[1] 梁民[1] 莫裕春[1] 李少云[1] 

机构地区：[1]广西南宁市第二人民医院眼科,530031

出　　处：《中国医疗前沿》2011年第11期9-10,共2页China Healthcare Innovation

摘　　要：目的比较下方自体角膜缘干细胞移植术与上方自体角膜缘干细胞移植术治疗翼状胬肉的临床疗效。方法翼状胬肉患者83例100只眼,随机分为两组(下方自体角膜缘干细胞移植组及上方自体角膜缘干细胞组)每组50只眼,失访5例(8只眼)。分别行下方自体角膜缘干细胞移植术和上方自体角膜缘干细胞移植术治疗,术后随访2年。结果两组取材区角膜部位均有角膜缘白色云翳或斑翳,结膜部位无明显瘢痕。角膜创面上皮平均愈合时间下方自体角膜缘干细胞移植组为5.51d(5.51±1.14),上方自体角膜缘干细胞移植术组为6.35d(6.35±1.20),两组比较差异有显著性(F=3.727,P<0.05)。下方自体角膜缘干细胞移植组(45只眼)1只眼复发,复发率为2.22%;上方自体角膜缘干细胞移植术组(47只眼)7只眼复发,复发率为14.89%,两组比较差异有显著性意义(χ2=4.78,P<0.05)。结论自体角膜缘干细胞移植术能使角膜创面修复快,复发率低,是一种理想的手术方法。下方自体角膜缘干细胞移植术术后角膜上皮愈合时间更短,而且遗留的角膜缘部位瘢痕对患者以后进行的眼科手术解剖部位无明显影响而值得推广用。Objective To evaluate the therapeutic effects of pterygium treated by bottom and top limbal stem cell autograft transplantation.Methods 100 eyes of 83 patientes with pterygium were divided into two groups,each group had 50 eyes,and there are 5 patientes（8 eyes） had beed losted to follow-up.They were treated by bottom and top limbal stem cell autograft transplantation.All the patients have been followed 2 years.Results Parts of the two groups were derived of white clouds or spots shade in corneal limbal area,but the conjunctival sites had no scar.The bottom limbal stem cell transplantation group＇s average healing time of the epithelial corneal wound was 5.51（5.51±1.14）days,and the other group was 6.35（6.35±1.20）days,the difference had statistical significance（F=3.727,P〈0.05）.the bottom limbal stem cell transplantation group had 1 eye recurrence,it＇s recurrence rate was 2.22%;and there were 7 eyes recurrenced in the bottom limbal stem cell transplantation group,it＇s recurrence rate was 14.89%,the difference had statistical significance（χ^2=4.78,P〈0.05）.Conclusion Not only can limbal stem cell transplantation make the corneal wound repairing quickly,but also reduce the recurrence rate,so it is an ideal surgical method.The corneal epithelial healing time of bottom limbal stem cell transplantation is shorter,And the scar left on the part of the limbus of eye surgery patients later had no effect on the anatomy and should be widely applied.

关 键 词：翼状胬肉 角膜缘干细胞 移植术 

分 类 号：R777.3[医药卫生—眼科]