抑制元素-1沉默转录因子和N-甲基-D-天冬氨酸受体-1在人脑胶质瘤中的表达及意义  

Expression and Significance of REST/NRSF and NMDAR1 in Human Glioma

作　　者：杨旋[1] 张捷[1] 文志华[1] 袁先厚[1] 

机构地区：[1]武汉大学中南医院神经外科,湖北武汉430071

出　　处：《医学新知》2011年第3期182-184,F0004,共4页New Medicine

摘　　要：目的探讨抑制元素-1沉默转录因子（repressor element silencing transcription factor, REST）／神经元限制性沉默因子 （ neuron - restrictive silencer factor, NRSF）和N-甲基-D-天冬氨酸受体-1（NMDAR1）在人脑胶质瘤中的表达及意义。方法采用免疫组织化学方法检测40例人脑胶质瘤标本中REST／NRSF和NMDAR1的表达。结果40例人脑胶质瘤标本中可以观察到REST／NRSF和NMDAR1的阳性表达，而且随着胶质瘤病理级别的提高阳性表达逐渐增强，两者的表达呈正相关。结论REST／NRSF和NMDAR1可能在人脑胶质瘤的发生发展过程中起比较重要的作用，而且对于判断胶质瘤的恶性程度和预后具有-定的参考意义，Objective To explore the expression and the significance of REST/NRSF and NMDAR1 in human glioma. Methods Expressions of NRSF/REST and NMDAR1 were detected by immunohistochemical technique in 40 cases of glioma. Results The expressions of NRSF/REST and NMDAR1 in glioma were correlated with its pathological grade. The expression levels of NRSF/REST and NMDAR1 were higher in glioma grade of III and IV than those in the grades of I and II. Conclusion NRSF/REST and NMDAR1 are expressed in human gliomas,which may play an important role in the progression of glioma.

关 键 词：胶质瘤 REST NRSF NMDAR 

分 类 号：R739.41[医药卫生—肿瘤]