Survivin和Caspase-3在结肠癌和结肠腺瘤组织中的表达及意义  

Expressions of Survivin and Caspase-3 in Tissues of Colonic Cancer and Colonic Adenoma and their Signifi-cances

作　　者：刘冬[1] 赵勇[1] 

机构地区：[1]河南省焦作煤业集团中央医院外科,454000

出　　处：《中外妇儿健康（学术版）》2011年第4期53-54,共2页

摘　　要：为探讨Survivinfp Caspase-3在结肠癌和结肠腺瘤组织中的表达及意义,应用免疫组织化学染色法对42例结肠癌正常黏膜组织、38例结肠腺瘤组织进行Survivin和Caspase-3检测。结果显示,结肠癌组织中Survivin阳性率明显高于结肠腺瘤和结肠正常黏膜组织(P<0.05)结肠癌组织中Caspase-3阳性率明显低于结肠腺瘤组织(P<0.05)。Survivine-3在结肠癌组织中的表达呈负相关(r--0.8535,P=0.000)。结果表明,Survivin可能通过抑制结肠癌细胞凋亡,对肠癌的发生发展起重要作用;在结肠癌的癌变过程Survivin的作用可能是通过抑制Caspase-3介导的细胞凋亡实现的。In this studv by usine immunohistochemistry stain method Survivin and Caspase-3were detected in the colonic cancer tissue and normal tissue of 42patients,and colonic adenoma tissue of 38patients so as to investigate the expressions of the two proteins and their significance.As results,the positive expression rate of Survivin in the tissue of colonic cancer was significantly higher than that in other two tissues（P 0.05）;the positive expression rate of Caspase-3in the tissue of colonic cancer was.significantly lower thanthat in the tissue of colonic adenoma（P0.05）;and in the tissue of colonic cancer the expression of Survivin was negatively related with that of Caspase-3（r=一0.8535,P=0.000）.Results show that Survivin could play the important role in formation and development of colonic cancer,through inhibiting the apoptosis of colonic cancer cells,while,Survivin through inhibiting the cell apoptosis mediated by Caspase-3could perform its role in the carcinomatous conversion.

关 键 词：结肠癌 结肠腺瘤Survivin CASPASE-3 免疫组织化学 

分 类 号：R735.35[医药卫生—肿瘤]