大鼠局灶性脑缺血细胞因子介导的中性粒细胞化学吸附剂的动态观察  

Dynamic investigation of cytokin-induced neutrophil chemoattractant in rats with focal cerebral ischemia

作　　者：曹学兵[1] 黄怀钧[2] 王凤霞[2] 孙圣刚[1] 

机构地区：[1]同济医科大学附属协和医院,430022 [2]湖北医科大学附属第二医院种经内科

出　　处：《卒中与神经疾病》1999年第4期208-210,共3页Stroke and Nervous Diseases

摘　　要：目的；探索细胞因子介导的中性粒细胞化学吸附剂（CINC）在脑缺血损伤中的作用。方法：用线栓法制备大鼠局灶性脑缺血模型，观察不同脑缺血时程血浆（sera）和脑组织内CINC浓度与髓质过氧化物酶（MPO）活性。结果：缺血组，血浆中CINC浓度的高峰在缺血6小时，脑组织内CINC浓度和髓质过氧化物酶（MPO）活性均呈低水平，其中CINC浓度高峰在缺血12小时，与对照组比较，差异均有极显著性意义（P＜0．01）；血浆中MPO活性随着缺血时间延长而逐渐升高，缺血6小时以上各组与对照组比较差异均有极显著性意义（P＜0．01）；脑组织内各组MPO活性差异无显著性意义（P＜0．05）。结论：缺血时。objective: To explore the effect of cytokin - induced neutrophil chemoattractant (CINC)inischemic cerebral injury. Methods: In different time, the concentrations of CINC and the activities ofmyeloperioxidase (MPO)were observed in rats with focal cerebral ischemic model rats made by thread embolismmethod. Results: The peaks of the CINC concentrations in sera were in 6 hour and cerebral tissue in 12 hour afterischemia respectively, which were significantly higher than those of the control (P<0. 01 ); The MPO activities ofcerebral tissues in ischemic groups were no significant change (P > 0. 05), Following the ischemia, the MPOactivities in sera elevated accordingly. the MPO activities after 6 hour ischemia were significantly higher than thoseof the control (P<0. 01 ). Conclusion: The CINC may be a trigger resulting in ischemic cerebral injury during thecerebral ischemia.[

关 键 词：细胞因子介导 化学吸附剂 CINC MPO 脑缺血 

分 类 号：R743.31[医药卫生—神经病学与精神病学]