超早期溶栓联合神经保护剂治疗急性脑梗死的临床研究  

A clinical study of ultra-early thrombolytic therapy combination of neuronal protective drugs in acute cerebral infarction

作　　者：周宏斌[1] 常丽英[1] 郭凡荣[1] 王家泉[1] 张允键 王淑媛[1] 

机构地区：[1]湖北省襄樊市中心医院神经内科,441021

出　　处：《卒中与神经疾病》1999年第4期213-215,共3页Stroke and Nervous Diseases

摘　　要：目的：研究尿激酶（UK）溶栓治疗的疗效、最佳时机、安全性及神经保护剂对溶栓疗效的影响。方法：45例急性脑梗死患者，起病6小时内30例，6～12小时15例，根据起病时间及是否使用神经保护剂分为A、B、C三级，快速静脉滴注尿激酶50～80万单位，另设对照组30例，分别对治疗前、后患者神经功能缺损及疗效进行评定。结果：UK治疗组与对照组相比神经功能缺损评分下降显著，A、B组（＜6小时组）P＜0．01；C组（6～12小时组）P＜0．05。使用神经保护剂组治愈率明显提高，6小时以内组溶栓无一例出现并发症。结论：UK小剂量超早期（＜6小时）静脉溶栓疗效显著，并发症少，神经保护剂能提高溶栓疗效。: To study the curative effect, the best time, safety of thrombolytic therapy withuroinase (UK),and ralationship with neuroprotectants. Methods: 45 cases suffered from acute cerebral infarction,<6 hour(30cases ), >6 hour and <l2 hour (15casea )after onset of ischemic stroke. lt was divided into three types(A, B, C) accrording to the time after onset of ischemic stroke or using neuropotectants, and 30 cases nornalcontrals using UK by 500 ~ 800 thousand unit intravanous injection. After treatment, the scale of neurologicaldeficit and efficacy were used for functional assessment. Result: The scale of neutoloyical deficit of thrombolytictherapy with UK was significantly lower than those in controls. A,B types (<6 hour),P<0. 0l,C type (>6hourand < l2 hour ), P < 0. 05. The curative effect digificantly increased by using neuroprotectants, and no furtherdamage was found in A, B types. Conclusion: ultra-early(<6 hour)thronbolytic therapy of using UK of small doseis positive effect and safety, neuroprotectants can significantly increase the curative effect.[

关 键 词：尿激酶 脑梗死 神经保护剂 溶栓疗法 

分 类 号：R743.330.5[医药卫生—神经病学与精神病学]