^99Tc^m-甲氧基异丁基异腈显像对可手术乳腺癌新辅助化疗疗效的预测价值  

Predictive value of ^99Tc^m-MIBI scintimammography in evaluation of the efficacy of neoadjuvant chemotherapy in patients with operable breast cancer

作　　者：刘真真[1] 卢振铎[1] 张恒伟[1] 杨辉[2] 刘慧[1] 李连方[1] 李文亮[2] 崔树德[1] 

机构地区：[1]河南省肿瘤医院郑州大学附属肿瘤医院乳腺病诊疗中心,450008 [2]河南省肿瘤医院郑州大学附属肿瘤医院核医学科,450008

出　　处：《中华肿瘤杂志》2011年第7期544-546,共3页Chinese Journal of Oncology

基　　金：基金项目：河南省科技攻关项目（0324410051）

摘　　要：目的研究^99Tc^m-甲氧基异丁基异腈（^99Tc^m-MIBI）亲肿瘤显像在叮于术乳腺癌新辅助化疗疗效及预后预测中的价值。方法对65例拟行新辅助化疗的可手术乳腺癌患者进行^99Tc^m-MIBI显像，采集10和180min两时相的平面像，计算放射性清除率，分析清除率勺化疗疗效和患者无病生存率的关系。结果65例乳腺癌患者^99Tc^m-MIBI显像的放射性清除率为（17．4±6．8）％。新辅助化疗达完全缓解4例，部分缓解52例，疾病稳定8例，疾病进展1例，有效率为86．2％。新辅助化疗有效组和无效组的放射性清除率分别为（15．5±5．0）％和（29．2±3．2）％，差异有统计学意义（P〈0．001）。高清除率组乳腺癌患者的无病生存率（53．1％）显著低于低清除率组（75．8％，P=0．046）。结论^99Tc^m-MIBI显像清除率可用于可手术乳腺癌新辅助化疗疗效的预测，并具有一定的预后价值。。Objective To investigate the value of technetium-99m methoxyisobutylisonitrile （^99Tc^m- MIBI ） imaging in predicting the efficacy of neoadjuvant chemotherapy （NCT） and prognosis in patients with operable breast cancer. Methods Sixty five patients with breast cancer underwent 99Tcm-MIBI scintimammography before NCT, and static planar images were taken at 10 min and 180 rain after scintimammography. The clearance rate was calculated in each patient, correlation between the clearance rate and efficacy of NCT, and the disease free survival rate were analyzed. Results The mean clearance rate of 65 patients was （ 17.4 ±6.8） %. The efficacy of NCT was 86.2% （ CR 4 cases, PR 52 cases, SD 8 cases, and PD 1 case） , and the mean clearance rate of patients with good response or poor response of chemotherapy were （ 15.5 ± 5.0） % and （ 29.2 ± 3.2 ） %, respectively. There was a significant difference between the two groups. The average disease free survival rate in the group with low clearance rate was （75.8%, P = 0. 046）, significantly higher than that in the group with high clearance rate （53.1%）. Conclusion Scintimammography of ^99Tc^m-MIBI may be used to evaluate the efficacy and prognosis of NCT for patients with operable breast cancer.

关 键 词：乳腺肿瘤 放射性核素显像 新辅助化疗 甲氧基异丁基异腈 预后 

分 类 号：R737.9[医药卫生—肿瘤]