急性颞顶叶局灶性脑梗死后胼胝体DTI变化的初步研究  

The Initial Study of DTI Change of Corpus Callosum after Focal Acute Cerebral Temporal Lobe and Parietal Lobe Infarctions

作　　者：杨军乐[1] 高燕军[1] 徐敏[1] 马鸣岳[1] 宁文德[1] 郭佑民[2] 

机构地区：[1]西安交通大学医学院附属西安市中心医院放射科,西安710003 [2]西安交通大学医学院附属第一医院影像中心

出　　处：《临床放射学杂志》2011年第7期936-939,共4页Journal of Clinical Radiology

基　　金：陕西省科技厅科研基金资助项目(基金号:2008K11-02)

摘　　要：目的探讨一侧颞顶叶急性脑梗死梗死灶面积与胼胝体不同区域各向异性之间可能存在的变化。资料与方法连续采集病灶位于一侧颞叶、顶叶或一侧颞叶、顶叶均有病灶的急性脑梗死患者资料66例,男38例,女28例。年龄40～85岁,其中40～49岁10例,50～59岁18例,60～69岁20例,70岁以上18例。病灶面积≤200mm2者44例,>200 mm2者22例(剔除)。选取同期连续采集获得的与病变组44例匹配的正常成人作为对照分析组。病变组及正常组均行正中矢状位25梯度方向扩散张量成像(DTI)扫描,在正中矢状位部分各向异性(FA)图上分别测量胼胝体膝部、体部前1/3处、体部中部、体部后1/3处及压部的FA值,测量值进行统计分析。结果在胼胝体体部前1/3处、体部中部及体部后1/3处的FA值均为正常组大于病变组,其中体部前1/3处及体部后1/3处正常组与病变组之间差异存在统计学意义(t=2.838,P<0.05;t=8.223,P<0.05)。病变组胼胝体膝部及压部FA值均大于正常组,两组之间差异均有统计学意义(t=-3.428,P<0.05;t=-2.392,P<0.05)。结论颞顶部发生面积≤200 mm2的急性梗死时,功能上连接该部位的胼胝体的相应区域各向异性减低,而其他区域升高,可能与补偿及代偿有关。Objective To study the possible difference of infarct area with anisotropy of different regions of corpus callosum in acute cerebral temporal lobe and parietal lobe infarctions.Materials and Methods 66 patients with acute cerebral infarcts in temporal and/or parietal lobe were collected consecutively,the male and female were 38 and 28 respectively,aging from 40 to 85 years old,10 cases in 40~49,18 cases in 50~59,20 cases in 60~69 and 18 cases over 70 years old.The infarct area was less or equal to 200 mm2 in 44 cases,and more than 200 mm2 in 22 patients（eliminated）.44 patients match health adult volunteers were collected consecutively as control group in the same period.All cases were performed with diffusion tensor imaging with 25 diffusion gradient encoding direction.The fractional anisotropy（FA） values of the genu,anterior one-third,middle part,posterior one-third and splenium of the corpus callosum were measured in FA map.The FA values were analyzed.Results The FA values of anterior one-third,middle part and posterior one-third of the corpus callosum were higher in the control groups than that in the lesion groups,and there was significant difference in the anterior one-third and posterior one-third of the corpus callosum between the lesion groups and the control groups（t=2.838,P0.05;t=8.223,P0.05）.The FA values of genu and splenium of the corpus callosum were higher in the lesion groups than that in control groups,and there was significant difference between the two groups（t=-3.428,P0.05;t=-2.392,P0.05）.Conclusion The FA values are decreased in the corresponding regions of the corpus callosum with infarct area less or equal to 200 mm2,the FA values of other regions are increased for compensatory and/or complementary.

关 键 词：急性脑梗死 胼胝体 各向异性 扩散张量成像 磁共振成像 

分 类 号：R743.33[医药卫生—神经病学与精神病学]