低中危局限期前列腺癌外照射计划的剂量学研究  

Dosimetry study of external radiotherapy for patients with limited-stage prostate cancer

作　　者：徐志勇[1] 董勇[1] 孙一[1] 陈定科 刘勤发[1] 

机构地区：[1]广东省东莞市石龙人民医院肿瘤科,广东东莞523326

出　　处：《吉林医学》2011年第19期3885-3887,共3页Jilin Medical Journal

基　　金：广东省东莞市科技计划项目[编号:0769-81368907]

摘　　要：目的:分析比较低中危局限期前列腺癌治疗的三维适形(3D CRT)和调强(IMRT)放疗计划。方法:调取5例局限期前列腺癌患者的定位CT数据资料,采用VENUS TPS,按照两种治疗计划设计和计算,分析剂量——体积直方图,比较剂量分布的差异。结果:临床靶区的剂量覆盖均可达到理想的剂量分布;对于计划靶区(CTV)V95、D95和适形指数在IMRT为99%、96%和0.88,在3D CRT为95.1%、93.3%和0.70;剂量不均整性无明显差异。同时满足直肠D50为50 Gy、D25为70Gy,膀胱D50为50 Gy、D30为65 Gy和股骨颈D95为50 Gy的耐受剂量时,靶区最大处方剂量IMRT和3D CRT分别为88.25 Gy和73.27 Gy。结论:低中危局限期前列腺癌的放疗,在保证直肠、膀胱及股骨颈不超过最大耐受量时,IMRT和3D CRT均可达到满意的剂量分布,IMRT能够更好地保护正常组织,降低放疗不良反应。Objective To assess and compare the radiation plan of three dimension conformal radiation therapy（3D-CRT） and intensity modulated radiation therapy（IMRT） for limited-stage prostate cancer.Method A dosimetry study was carried out on 5 limited-stage prostate cancer patients.Dose volume histogram（DVH）of the above two techniques were carried out on every one of these 5 patients.Results Compared with 3D-CRT,the clinical target volume of IMRT has the same dose distribution,and IMRT has better protection of normal tissue.Conclusion Trying to obtain the highest safe prescription dose which can satisfy the restriction of rectum,bladder and femoral head,the two techniques enable us to apply a radical treatment dose.IMRT can protect of normal tissue more,the rate of toxicity of the surrounding tissues is lower then 3D-CRT.

关 键 词：放射疗法 前列腺肿瘤 剂量学 

分 类 号：R737.25[医药卫生—肿瘤]