血管内激光照射对犬急性心肌缺血区血液流变学的影响  

Hemorheological changes in acute ischemic region of dog due to coronary stenosis caused by laser irradiation on blood

作　　者：杨继庆[1] 张建保[1] 王跃民[2] 范云[1] 

机构地区：[1]第四军医大学物理学教研室,西安710032 [2]第四军医大学生理学教研室,西安710032

出　　处：《心功能杂志》1999年第4期228-229,共2页

摘　　要：健康杂种犬，开胸分离冠状动脉前降支，并造成冠状动脉狭窄。在狭窄１２０ ｍ ｉｎ 后将ＨｅＮｅ激光（输出功率２．４６±０．１１ ｍ Ｗ）经石英光纤插入下肢体大动脉，照射６０ ｍ ｉｎ。照射后其全血高切和低切粘度较照射前各减少１１％ 和１４％ ，血浆粘度降低６％ ，红血细胞压积减少５％ ，纤维蛋白原下降１４％ ，均变化显著。对照组则无显著性变化。结果表明激光血管内照射（ＩＬＩＢ）可降低纤维蛋白原浓度，改善红细胞的变形性，进而导致血浆粘度与全血粘度降低。HeNe laser irradiation on blood (ILIB) was applied to the model with severe stenosis of the left anterior descending coronary artery from healthy dogs. After 120 min of the stenosis HeNe laser was input into the lower limb artery with an optical fiber and the radiation lasted 60 min. The experiment showed that after the radiation,the whole blood high shear viscosity,the whole blood low shear viscosity,plasma viscosity,and hemotacrit level and fibrinogen level decreased 11%,14%,6%,5% and 14% respectively ( P <0.05),as compared with those before the radiation. But no changes were observed in the control group. The results indicate that ILIB can improve the hemorheological performance and fluidity of blood in the ischemic region.

关 键 词：心肌缺血 激光疗法 血液流变学 血管内 激光照射 

分 类 号：R542.205[医药卫生—心血管疾病] R454.2[医药卫生—内科学]