超声测量早孕期胎盘厚度评价胎儿重型α地中海贫血风险性的研究  

Research on values of ultrasound measuring of placenta thickness at the early pregnancy for evaluating risks of alpha-thalassemia

作　　者：马燕[1] 梁洁梅[3] 李智贤[1] 李敏清[2] 马海英[1] 廖新红[1] 叶桂宏[1] 

机构地区：[1]广西医科大学第一附属医院超声科,南宁530021 [2]广西医科大学第一附属医院产前诊断中心,南宁530021 [3]广西壮族自治区妇幼保健院超声科

出　　处：《中华超声影像学杂志》2011年第7期609-612,共4页Chinese Journal of Ultrasonography

基　　金：基金项目：广西科学基金资助项目（桂科自0640111）;国家“十一五”科技支撑计划项目（2007BA107A17-11）

摘　　要：目的 探讨早孕期超声测量胎盘厚度对评价胎儿重型α地中海贫血风险性的价值.方法 对208例具有α地中海贫血风险的早孕期胎儿和对照组52例正常胎儿行二维超声检查,测量胎盘厚度.胎盘厚度用中位数的倍数（ MOM）表示.结果 早孕期重型α地中海贫血胎儿胎盘厚度明显高于中间型、轻型α地中海贫血胎儿和正常胎儿,差异有统计学意义（P＜0.001）;其他各组胎盘厚度两两比较,差异无统计学意义（P=0.100）.α地中海贫血高危胎儿胎盘厚度提示重型α地中海贫血风险性高的最佳临界点为 1.18 MOM.胎盘厚度〉1.18 MOM提示重型α地中海贫血风险性高的灵敏度、特异度分别为 82.9%,84.7%.结论 胎盘厚度是评价胎儿患重型α地中海贫血风险性的一项安全、有效的指标,可以减少不必要的侵入性操作,提高重型α地中海贫血胎儿检出率.Objective To investigate the values of ultrasound measuring of the placenta thickness on evaluation of risks for alpha-thalassemia at the early pregnancy.Methods Two-dimensional ultrasound was performed to measure the thickness of placenta on 208 cases of fetuses with alpha-thalassemia and 52 cases of normal fetuses in control group.The placenta thickness was expressed as multiples of the median（MOM）.Results At the early pregnancy,the group of fetuses with alpha-thalassemia had significantly higher placenta thickness compared to the fetuses without alpha-thalassemia（P〈0.001）.However,there were no statistical significant difference in the placenta thickness between the other groups（P=0.100）.Placenta thickness 1.18 MOM was the best critical point to predict alpha-thalassemia.The sensitivity and specificity of placenta thickness 〉1.18 MOM in prediction of alpha-thalassemia was 82.9%,84.7% respectively.Conclusions For those with high risks of alpha-thalassemia placenta thickness measuring is a safe,effective parameter for assessment because it could reduce unnecessary invasive procedures and improve the detecting rate of severe alpha-thalassemia.

关 键 词：超声检查 产前 Α地中海贫血 胎盘厚度 妊娠初期 

分 类 号：R714.5[医药卫生—妇产科学]