利培酮与舒必利治疗精神分裂症对照研究  

A controlled trial comparing the efficacy of risperidone and sulpiride in the treatment of schizophrenia

作　　者：翁正[1] 张敬悬[1] 韩克和[2] 张敦平[2] 孙树花 贾继敏 周桂华[4] 毕崇波[4] 梁文香 王佳玲 王贵山[6] 陈洪[6] 余西金 韩希海 陈刚[1] 李涛 王丽娟[9] 

机构地区：[1]山东省精神卫生中心,250014 [2]山东淄博市精神病医院 [3]滨州地区第三人民医院 [4]潍坊市精神卫生中心 [5]枣庄市立二院 [6]济宁市精神病防治院 [7]临沂地区复退军人精神病院 [8]烟台市莱阳精神病医院 [9]江苏南通市通济医院

出　　处：《临床精神医学杂志》1999年第6期331-333,共3页Journal of Clinical Psychiatry

摘　　要：目的： 比较利培酮与舒必利对精神分裂症的临床疗效及对各症状群的作用特点， 观察其副作用。　方法： 将符合入组标准的精神分裂症患者随机分为利培酮与舒必利两组，用阳性与阴性症状量表 （ＰＡＮＳＳ）、简明精神病评定量表 （ＢＰＲＳ）、临床疗效总评 （ＣＧＩ）、阴性症状量表 （ＳＡＮＳ） 和副反应量表（ＴＥＳＳ） 等评定其疗效和副反应。　结果： 利培酮组疗效优于舒必利组， 对阴性症状的效果更显著。ＴＥＳＳ总分两组间差异无显著性。　结论： 利培酮对精神分裂症的疗效优于舒必利， 对阴性症状效果更为突出。Objective:To study the efficacy and side effect of risperidone and sulpiride in the treatment of schizophrenia. Method:Patients with diagnosis of schizophrenia and fulfilling the admission criteria to the study were randomly assigned to two groups that were treated with either risperidone or sulpiride. The therapeutic response and side effects were evaluated with the PANSS, SANS, BPRS, CGI and TESS. Results:The overall therapeutic effect of risperidone were superior to that of sulpiride with significant difference as measured with the PANSS, SANS and CGI. However, there was on statistical difference in the TESS score between the two groups. Conclusion:Risperidone is superior than sulpiride in the treatment of schizophrenia,especially the negative symptoms.

关 键 词：利培酮 舒必利 精神分裂症 药物疗法 

分 类 号：R749.305[医药卫生—神经病学与精神病学] R971.4[医药卫生—临床医学]