无机三氧化复合物在乳磨牙牙髓切断术中应用价值的系统评价  

Mineral trioxide aggregate as a pulp capping agent in primary molar pulpotomy:a systematic review

作　　者：黄晶洁[1,2] 张荣德 赵媛[2] 田金徽[1] 陈莉娅[4] 

机构地区：[1]兰州大学循证医学中心,甘肃兰州730000 [2]兰州大学口腔医学院,甘肃兰州730000 [3]兰州市城关区人民医院,甘肃兰州730000 [4]兰州大学第一医院,甘肃兰州730000

出　　处：《牙体牙髓牙周病学杂志》2011年第7期400-404,419,共6页Chinese Journal of Conservative Dentistry

基　　金：甘肃省第七批科技计划(青年科技基金)(1007RJYA009);中央高校自由探索项目(lzujbky-2009-143)

摘　　要：目的:评价无机三氧化复合物(MTA)在乳磨牙牙髓切断术中的疗效。方法:计算机检索PubMed、Cochrane Library、EMBASE、中国生物医学文献数据库、中国期刊全文数据库、中文科技期刊全文数据库、数字化期刊全文数据库,同时追溯纳入研究的参考文献。根据Cochrane系统评价的方法,采用RevMan5.0软件进行Meta分析。评价指标包括:临床成功率和影像学成功率。结果:共纳入11个研究,730个病例。Meta分析结果显示,与甲醛甲酚(FC)相比,MTA可提高乳磨牙牙髓切断术的临床成功率[OR=3.41,95%CI(1.38,8.37),P=0.008]及影像学成功率[OR=3.14,95%CI(1.61,6.14),P=0.0008];MTA与氢氧化钙(CH)相比,在乳磨牙牙髓切断术的临床成功率[OR=3.17,95%CI(0.08,128.60),P=0.54]和影像学成功率[OR=8.29,95%CI:(0.39,177.26),P=0.18]方面的差异均无统计学意义。结论:MTA作为一种新型的盖髓剂,与FC相比,可提高乳磨牙牙髓切断术的临床成功率和影像学成功率,与氢氧化钙相比,临床、影像学成功率无显著性差异。AIM： To evaluate the effectiveness of mineral trioxide aggregate （ MTA ） on pulpotomy in primary molars. METHODS： We searched PubMed, Cochrane Libra,＇y, EMBASE, Chinese Biomedical Literature Database and China Journal Full-text Database, Chinese Scientific Journals Full-text Database and Wan Fang Database. We also traced back the references to collect the relevant trials. According to the Cochrane Handbook for systematic reviews of interventions 5.0 statistic analyses were made using Revman 5.0 software. RESULTS ： Eleven studies were selected and 730 patients were included. Meta-analysis showed that ： in comparison with formocresol （FC） , MTA as a pulp capping agent in primary molar pulpotomy had a higher clinical success rate [ OR = 3.41, 95% CI （ 1.38, 8.37）, P =0.008land radiographic success rate [OR =3.14, 95% CI（1.61, 6.14）, P=0.0008]. MTA and calcium hydroxide（CH） showed no statistically significant difference in clinical success rate [ OR = 3.17, 95% CI（0.08, 128.60）, P = 0.54 ] and radiographic success rate [ OR = 8.29,95 % CI ： （0.39,177.26）, P = 0.18 ] when used for pulptomy dressing. CONCLUSION： Currently available evidence suggests that MTA as a pulpotomy medicament showed significantly higher clinical and radiographic successes than FC, but it showed no statistically significant difference in clinical and radiographic successes as compared with CH.

关 键 词：MTA 牙髓切断术 随机对照研究 系统评价 

分 类 号：R788.2[医药卫生—口腔医学]