宫颈癌中MTA1蛋白的表达及临床意义  

The Expression and Clinical Significance of MTA1 Protein in Cervical Cancers

作　　者：韩肖燕[1,2] 钱海利[3] 林晨[3] 张雪燕[3] 梁萧[3] 付明[3] 杨隽钧[1] 向阳[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院,北京100730 [2]首都医科大学附属北京友谊医院 [3]中国医学科学院肿瘤医院肿瘤研究所,北京100021

出　　处：《实用妇产科杂志》2011年第7期511-514,共4页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:研究转移相关基因1(MTA1)在宫颈癌中的表达及临床意义。方法:采用免疫组化法检测20例正常宫颈组织,50例宫颈癌以及淋巴结转移癌组织中MTA1蛋白的表达情况,并与临床病理特征相比较。结果:与正常宫颈上皮相比,宫颈癌与淋巴结转移癌组织中MTA1阳性细胞数量及染色强度均明显增高。正常宫颈中MTA1蛋白定位于细胞核;宫颈癌及淋巴结转移癌组织中MTA1出现了细胞核、细胞浆、细胞膜的多种形式的蛋白定位。宫颈癌中MTA1蛋白的过表达与淋巴转移、浸润深度及脉管浸润有关,与组织学类型、分化程度无关。Kaplan-Meier生存分析未发现MTA1是宫颈癌的不良预后因素。结论:MTA1蛋白的过表达可能与宫颈癌的发生发展、浸润转移密切相关,其与宫颈癌预后的关系还有待于进一步研究。Objective：To investigate the expression and clinical significance of MTA1（metastasis-associated gene 1） protein in cervical cancers.Methods：MTA1 expression and correlation with clinico-pathological features were explored in 20 normal cervical tissues,50 cervical cancers by immunohistochemistry.Results：The MTA1 protein was located in the cellular nuclei of normal cervical tissues,while it distributed both in cytoplasm and/or on membrane besides nuclei in cervical cancer and metastatic lymph nodes.The expression level of MTA1 in cervical cancer tissues and metastatic lymph nodes were significantly higher than that in normal cervical tissues.Overexpression of MTA1 was correlated with lymph nodes metastasis,the depth of infiltration and vascular involvement.The relationship of MTA1 protein with histological type and tumor differentiation was not found.Kaplan-Meier survival analysis did not show MTA1 was a prognostic factor.Conclusions： The overexpression of MTA1 may play a role in the carcinogenesis,development,invasion and metastasis of cervical cancers.The relationship between MTA1 expression and prognosis of cervical cancers still needs to be further explored.

关 键 词：宫颈癌 转移相关基因1 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]