同源框基因HOXA11及雌激素受体在人良、恶性子宫内膜增殖组织中的表达及意义  

Expression and Significance of HOXA11 Gene and Estrogen Receptor in Benign and Malignant Endometrial Hyperplasia

作　　者：陈琦[1] 谭布珍[1] 高国兰[2] 丰颖[1] 

机构地区：[1]南昌大学第二附属医院,江西南昌330006 [2]北京航空总医院,北京100012

出　　处：《实用妇产科杂志》2011年第7期530-532,共3页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:探讨同源框基因HOXA11及雌激素受体(ER)在人良、恶性子宫内膜增殖组织中的表达及意义。方法:采用Wester blot方法检测27例正常增殖期子宫内膜、35例单纯型及复杂型增殖子宫内膜、37例不典型增殖子宫内膜、31例子宫内膜腺癌组织中HOXA11和ER的表达。结果:HOXA11与ER蛋白的表达量由良性到恶性演变的子宫内膜呈下降趋势,组间比较,差异有高度统计学意义(P<0.001);且各组子宫内膜中HOXA11与ER蛋白的表达水平呈明显正相关(r=0.971,P=0.000)。结论:子宫内膜由良性到恶性演变的过程中,HOXA11与ER蛋白的表达量呈下降趋势,这两个指标对子宫内膜恶性病变的进程与预后具有一定的预测价值。Objective：To investigate the expression and significance of HOXA11and ER in benign and malignant endometrial hyperplasia.Methods：27 proliferative endometrial samples,35 simple and complex hyperplasia without atypical change,37 atypia hyperplasia,31 endometrial carcinoma tissues were obtained,and the expressions of HOXA11 and ER protein were detected by Western blot.Results：The expression of HOXA11 and ER protein gradually decreased from benign to malignant hyperplasia of endometrial,the differences among different groups were significant（P〈0.001）.There was a significantly positive correlation between HOXA11 and ER expression in different groups（r=0.971,P=0.000）.Conclusions：The expression of HOXA11 and ER protein gradually decreases from benign to malignant hyperplasia of endometrium,HOXA11 and ER might be the important biological and prognostic markers for endometrial malignant changes.

关 键 词：同源框基因HOXA11 雌激素受体 子宫内膜 子宫内膜癌 

分 类 号：R737.33[医药卫生—肿瘤]