雌激素及其受体对谷氨酸诱导神经细胞损伤的作用  

Effect of estrogen and its receptors on glutamate-induced neural cell injury

作　　者：张广云[1] 胡晓[2] 娄磊[3] 王建怡[3] 

机构地区：[1]贵阳医学院小儿内科,贵阳550002 [2]贵州省人民医院神经内科,贵阳550002 [3]贵州省人民医院小儿内科,贵阳550002

出　　处：《第二军医大学学报》2011年第7期795-798,共4页Academic Journal of Second Military Medical University

基　　金：贵州省科技厅攻关项目[黔科合sy(2009)3054];贵州省优秀科技教育人才省长专项资金[黔省专合字(2010)86号]~~

摘　　要：谷氨酸(glutamate,Glu)的兴奋毒性已被证实对神经细胞具有损伤作用。研究发现Glu的兴奋毒性导致神经细胞损伤在多种神经系统疾病的发病过程中起着重要作用,而雌激素对Glu毒性导致的神经细胞损伤具有保护作用,该作用可能是通过雌激素受体(estrogen receptor,ER)介导完成的。本文就雌激素及其受体对Glu诱导的神经细胞损伤的作用研究作一综述。It has been proven that glutamate-induced excitatory toxicity can bring damage to nerve cells.Previous studies indicate that glutamate excitotoxicity-associated neuron damage play an important role in the pathogenesis of a number of nervous system diseases,and estrogen can protect neurons from glutamate excitotoxicity-associated neuron damage,which may be mediated by estrogen receptor.This paper reviews the latest progress regarding the protective effects of estrogen and its receptors against glutamate-induced neuron damage.

关 键 词：雌激素类 雌激素受体 谷氨酸 神经细胞损伤 

分 类 号：R741.02[医药卫生—神经病学与精神病学]