PINCH蛋白在预测非小细胞肺癌淋巴结转移及预后的作用研究  

Expression of PINCH and Its Predictive Study on Lymphnode Metastasis and Prognosis of Non-small Cell Lung Carcinoma

作　　者：赵健[1] 赵振兴[1] 袁凤辉[1] 

机构地区：[1]河北省唐山市开滦医院,河北唐山063000

出　　处：《实用预防医学》2011年第7期1198-1200,共3页Practical Preventive Medicine

摘　　要：目的探讨PINCH蛋白在非小细胞肺癌(NSCLC)中的表达及其与淋巴结转移和患者预后之间的关系。方法应用免疫组化EnVision法检测185例NSCLC及癌旁组织中PINCH蛋白的表达,分析其表达与患者术后淋巴结转移及预后之间的关系。结果 NSCLC组织中PINCH阳性表达率明显高于癌旁组织(P<0.01)。PINCH在NSCLC组织中的表达与淋巴结转移密切相关(P<0.01)。PINCH阳性表达组术后5年生存率为20.5%(16/78),而PINCH阴性表达组5年生存率为52.3%(56/107),两组间比较差异有统计学意义(P<0.05)。Cox回归多因素分析表明PINCH表达是影响NSCLC患者预后的独立预后因素(P<0.05)。结论 PINCH蛋白的表达可能在NSCLC发生淋巴结转移过程中发挥重要作用;检测其表达状态将可能有助于临床医生预测NSCLC患者的预后,并为NSCLC的分子靶向治疗提供新的靶点和思路。Objective To explore the expression of PINCH protein and the relationship between PINCH expression and lymphnode metastasis,prognosis in patients with non-small cell lung carcinoma（NSCLC）.Methods The expression of PINCH protein was detected with immunohistochemical EnVision plus non-hiotin technique in 185 cases of NSCLC and tumor-adjacent tissues,and the correlation with lymphnode metastasis and prognosis in NSCLC patients was analyzed.Results The positive expression rate of PINCH protein in NSCLC was significantly higher than that in tumor-adjacent tissues（P0.01）.The expression of PINCH protein in NSCLC was closely related to lymphnode metastasis（P0.01）.The 5-year survival rate of the patients with high expression of PINCH（20.5%,16/78） was significantly lower than those with low expression（52.3%,56/107）,and the difference was statistically significant（P0.05）.The Cox proportional-hazards regression model showed that PINCH protein was an independent factor of the prognosis for NSCLC patients（P0.05）.Conclusions PINCH may play an important role in the lymphnode metastasis of NSCLC.Detection of PINCH expression may be helpful to predict the prognosis of patients with NSCLC.It can serve as a new marker for molecular targeted therapy in NSCLC.

关 键 词：非小细胞肺癌 PINCH基因 淋巴结转移 预后 

分 类 号：R734.2[医药卫生—肿瘤]