谷胱甘肽S转移酶π在肾细胞癌的表达及临床意义  

Expression of Glutathione S transferase π in Primary Renal Cell Carcinoma and Its Clinical Significance

作　　者：张强[1] 陈梓甫[1] 陈文榜[1] 施作霖[1] 

机构地区：[1]福建省立医院,福州350001

出　　处：《福建医科大学学报》1999年第4期372-375,共4页Journal of Fujian Medical University

摘　　要：目的　从细胞浆表达水平对谷胱甘肽Ｓ转移酶π（ＧＳＴ－π）在肾细胞癌及正常肾组织中的表达机制进行探讨，以期为选择化疗方案提供参考，获得更有效的化疗效果。　方法　应用免疫组化对肾癌及正常肾组织中ＧＳＴ－π进行检测，并结合临床分级、分型、分期探讨其临床及生理意义。　结果　９６．３％ 的正常组织及４１．４％ 癌组织有ＧＳＴ－π表达，前者表达强于后者，表达强度与分级、分型、分期无关。　结论　各型肾癌均来源于肾近曲小管上皮，它继承了正常肾组织ＧＳＴ－π高表达的特性，发挥解毒作用而产生天然性多药耐药（ＭＤＲ）。选择ＧＳＴ－π低表达的患者并且针对ＭＤＲ机制采用相应的化疗药物进行化疗将有助于提高化疗有效率。Renal cell carcinoma(RCC) is one of the most drug resistant tumors \ The chemotherapy efficiency is only 7%～10%,which is one of main causes of poor prognosis in RCC By studying the mechanisms of multidrug resistance(MDR),we attend to find the reference for chemotherapy plan \ Methods\ 70 cases of paraffin embedded RCC tissue sections were analyzed for the presence of GST π by means of immunohistochemistry \ Results\ 96 3% normal kidney tissue and 41 4% RCC expressed GST π,the positive staining located in the normal epithelium cell plasma of the proximal tube or tumor cell plasma,the former is the stronger expresser \ The expression of GST π has no relationship to the differentiation,type and stage of RCC \ Conclusion\ Our research suggested that every type of RCC originates from proximal tube and inherits the overexpression of GST π,it play a role in detoxification,which produce the MDR \ We suggested that the patients with low level of GST π is the best indication of chemotherapy \ Electing different drug according to the mechanism should be the key to improve the efficiency of chemotherapy \;

关 键 词：肾细胞癌 多药耐药 GST-Π 免疫组织化学 

分 类 号：R737.11[医药卫生—肿瘤]