谷胱甘肽硫转移酶基因GSTM1与宣威肺癌易感性关系的研究  

The Relationship between Glutathione S-transferase M1 and Susceptibility to Xuanwei's Lung Cancer

作　　者：张剑青[1] 龙翔宇[2] 熊国盛[3] 方利洲[1] 赵芝焕[1] 戴路明[1] 

机构地区：[1]昆明医学院第一附属医院呼吸内二科,云南昆明650032 [2]广安市人民医院肿瘤科,四川广安638500 [3]昆明医学院第一附属医院胸外科,云南昆明650032

出　　处：《昆明医学院学报》2011年第6期56-58,67,共4页Journal of Kunming Medical College

基　　金：云南省教育厅科学研究基金资助项目(06Y211C)

摘　　要：目的探讨宣威地区谷胱苷肽硫转移酶(GSTM1)基因多态性与肺癌易感性的关系.方法选取宣威肺癌患者50例,正常对照组50例,采用聚合酶链式反应(PCR)和限制性片段长度多态性(RFLP)技术检测GSTM1的基因多态性.结果 GSTM1基因缺失型患肺癌的OR值为2.71(1.20～6.11),与对照组比较,差异有统计学意义(P<0.05).烧烟煤者发生肺癌的危险性升高(OR=3.78,P<0.01),结果发现缺失型基因且烧烟煤者患肺癌的风险明显增高OR值为9.23(2.24～38.29),经统计学检验,两组差别有统计学意义(P<0.01).结论 GSTM1基因缺失型患肺癌的危险性增加,烧烟煤者患肺癌的风险明显增高.Objective To investigate the relationship between GSTM1genetic polymorphism and lung cancer susceptibility in Xuanwei,China.Method In a case-control study,PCR and RFLP was used to identify the genotypes of GSTM1 in 50 lung cancer cases and 50 controls.Results GSTM1 polymorphism showed frequency distribution differences,OR=2.71（1.20～6.11）.There was a significant difference between the case group and the control group（P0.05）.Using bituminous coal was strongly associated with the risk of lung cancer（OR=3.78,P0.01）.People using bituminous coal with GSTM1（-/-）genotype had an odds ratio of lung cancer compared with people not using bituminous coal with GSTM1（＋/＋）genotype（OR=9.23（2.24～38.29,and there was a significant difference（P0.01）.Conclusions GSTM1 null genotype increases the risk of lung cancer,Persons using bituminous coal with GSTM1 null genotype have higher risk of lung cancer.

关 键 词：GSTM1 基因多态性 肺肿瘤 易感性 

分 类 号：R734.2[医药卫生—肿瘤]