β-Catenin和E-Cadherin在卵巢浆液性肿瘤中的表达及意义  

β-Catenin and E-Cadherin the expression and significance in ovarian serous tumor

作　　者：王芳[1] 李锋[1] 杨安强[1] 陈胜民[1] 李洪安[1] 郭长军[1] 潘晓琳[1] 

机构地区：[1]石河子大学医学院病理学教研室,新疆石河子832002

出　　处：《农垦医学》2011年第1期1-4,共4页Journal of Nongken Medicine

摘　　要：目的:探讨β-Catenin、E-Cadherin在卵巢浆液性肿瘤中的表达及意义。方法:应用免疫组织化学技术检测5例正常卵巢组织(NOT)、10例卵巢浆液性囊腺瘤(OSA)、18例卵巢浆液性交界性肿瘤(OSBT)及38例卵巢浆液性癌(OSC)石蜡包埋组织中β-Catenin、E-Cadherin表达情况,并结合OSC周围组织浸润、淋巴结转移情况进行分类和统计分析。结果:(1)β-Catenin的表达在NOT、OSA、OSBT及OSC四组间逐渐升高,其差异具有统计学意义(χ2=22.736,P<0.05),β-Catenin的表达在NOT、OSA、OSBT与OSC组两两相比,差异均具有统计学意义(P<0.05);(2)E-Cadherin的表达在NOT、OSA、OSBT及OSC四组间比较,差异具有统计学意义(χ2=16.357,P<0.05),NOT、OSA及OSBT三组间E-Cadherin表达逐渐升高(P<0.05),OSBT与OSC两组间E-Cadherin表达有降低趋势,但差异无统计学意义(P>0.05);(3)E-Cadherin在OSC浸润组中表达阴性率比无浸润组有增高趋势,但两组相比差异无统计学意义(P>0.05)。结论:(1)β-Catenin的表达可能在OSC的发生及演变过程中起促进作用,其表达随肿瘤的恶性程度增高而升高;(2)E-Cadherin的表达可能从NOT、OSA到OSBT的发生及演变过程中起促进作用,其表达程度逐渐升高,从OSBT到OSC表达程度逐渐降低趋势。E-Cadherin在OSC浸润组中表达降低或缺失可能与OSC的浸润有关。Objective：To study the β-Catenin,E-Cadherin in ovarian serous carcinoma and discusses both in function and significance in ovarian serous tumor.Methods：Using immunohistochemistry technical testing 5 cases of normal ovarian tissue（NOT）,10 cases of ovarian serous adenoma（OSA）,18 cases of ovarian serous borderline tumor（OSBT） and 38 cases of ovarian serous carcinoma（OSC） paraffin embedding organization β-Catenin,E-Cadherin expression,and combining OSC surrounding tissues infiltration,lymph node metastasis case classification and statistical analysis.Results：（1）The expression of β-Catenin in NOT,OSA,OSBT and OSC organization four groups is compared between a statistically significant difference（χ2=22.736,P0.05）,NOT,OSA,OSBT and OSC compared with each other,opposite difference was statistically significant（P0.05）;（2） The expression of E-Cadherin in NOT,OSA,OSBT and OSC organization four groups is compared between a statistically significant difference（χ2=16.357,P0.05）.OSA,OSBT compared with NOT organization,opposite difference was statistically significant（P0.05）;（3） In the OSC group E-Cadherin infiltrating the expression expression rate drop,compared with no infiltration rate of the reduced significantly（P0.05）. Conclusion：β-Catenin,E-Cadherin OSC evolution process of the likely to play a role,both the malignant tumor with the degree of changes;rise E-Cadherin OSC infiltrating groups in decline,tip OSC expressed in E-Cadherin and infiltrating relevant.

关 键 词：卵巢浆液性癌 Β-CATENIN E-CADHERIN 免疫组织化学 

分 类 号：R730.2[医药卫生—肿瘤]