奥沙利铂联合亚叶酸钙和氟尿嘧啶治疗中晚期食管癌的临床观察  

Clinical study of oxaliplatin combination with calcium folinate and flrorouracil in treatment of advanced esophageal carcinoma

作　　者：杨钰贤[1] 张述耀[2] 张盛奇[1] 庄晓文[1] 丘希辉[1] 

机构地区：[1]汕头大学医学院附属肿瘤医院中西结合科,广东省汕头515031 [2]汕头大学医学院附属肿瘤医院药剂科,广东省汕头515031

出　　处：《中国基层医药》2011年第13期1745-1746,共2页Chinese Journal of Primary Medicine and Pharmacy

基　　金：广东省汕头市重点科技计划项目（2009-70）

摘　　要：目的观察奥沙利铂（L—OHP）联合亚叶酸钙（cF）和氟尿嘧啶（5-Fu）治疗中晚期食管癌的近期疗效及毒副反应。方法61例晚期食管癌患者分为治疗组（30例）和对照组（31例）。治疗组给予奥沙利铂联合亚叶酸钙和氟尿嘧啶治疗；对照组给予顺铂联合亚叶酸钙和氟尿嘧啶治疗。结果治疗组和对照组的总有效率分别为43．3％和41．9％（P〉0．05）。中位疾病进展时间（TTP）分别为8．1个月和7．9个月。毒副反应方面，治疗组血液学毒性、口腔炎、脱发的发生率与对照组均差异无统计学意义（均P〉0．05）；Ⅲ-Ⅳ度恶心呕吐（P=0．028），腹泻（P=0．039），肾毒性（P=0．044）等毒副反应发生率均显著低于对照组；外周神经毒性的发生率显著高于对照组（P=0．010）。结论奥沙利铂联合亚叶酸钙和氟尿嘧啶治疗中晚期食管癌，疗效较好，且毒副作用较小，可作为一线化疗方案。Objective To evaluate the efficacy and toxicity of oxaliplatin in combination with calcium folinate and flrorouracil in treatment of advanced esophageal carcinoma. Methods 61 patients with advanced esophageal cancer were divided into treatment group（30 cases） and control group （31 cases）. Treatment group was given oxaliplatin combined with calcium folinate and flrorouracil;control group was given cisplatin and calcium folinate and flrorouracil. Results The overall response rate was 43.3% in the treatment group and 41.9% in control group（ P 〉 0.05）. The median time to progression（TIP） was 8.1 months vs. 7.9 months（ P 〉 0.05 ）. Compared with control group, the treatment group, the side effects of myelosuppression, stomasitis and alopecia were not significant difference （P 〉 0. 05 ） , grade Ⅲ-Ⅳ nausea and vomiting（ P = 0.028 ）, diarrhea （ P = 0. 039 ） and renal toxicity （ P = 0. 044 ） were lower,while the peripheral nerve toxicity （P = 0. 010） was higher. Conclusion The effect of oxaliplatin combined with calcium folinate and flrorouracil had satisfactory effect in the treatment of advanced esophageal carcinoma, and the poisonous side effect was low. It could be used as first-line chemotherapy regimen.

关 键 词：食管肿瘤 奥沙利铂 醛氢叶酸 氟尿嘧啶 

分 类 号：R735[医药卫生—肿瘤]