曲安奈德联合地塞米松治疗Ⅳ级甲状腺相关性眼病的临床研究  

Clinical study on teramcinoline combined with dexamethasone in teratment of the patients with the grado IV of thyriod associated pehthalmopathy

作　　者：张键[1] 孙立新[1] 胡丕清[1] 高建萍[1] 余德成[1] 李玲[1] 

机构地区：[1]常德市第一人民医院眼科,湖南省常德415000

出　　处：《中国基层医药》2011年第13期1755-1756,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的评价眶周注射曲安奈德联合地塞米松治疗Ⅳ级甲状腺相关性眼病（TAO）患者的效果。方法将90例TAO患者随机分为A、B、C三组，A组眶周注射曲安奈德20mg联合地塞米松2．5mg，每4周一次。B组单纯注射曲安奈德20mg，4周一次；C组口服泼尼松1mg／kg，每2周减少5mg，总疗程半年。每4周复查记录视力、眼压、睑裂大小、上睑迟落、眼球突出度、眼球运动度等，随访一年。结果A组和B组对眼球突出度及眼球运动度的改善作用明显，C疗效差、副作用大，其中A组作用时间最快，第4周有效率为93．3％，眼部症状改善最明显，第4周有效率为80．0％，并发症少。结论眶周注射曲安奈德联合地塞米松能更迅速有效地改善TAO患者眼球突出及眼球运动受限症状，且副作用少，临床上可常规首选应用。Objective To evaluate the effect of triamcinolone orbital injection combined with dexamethasone in treatment of the patients with the grade IV of thyriod associated ophthalmopathy. Methods NOSPEVS IV grade of 90 patients were randomly divided into three groups, Group A, orbital injection of triamcinolone combind with dexam- ethasone, Group B, simple injection of triamcinolone, Group C, oral prednisone therapy for half a year. To review each record of visual acuity intraocular pressure palpebral fissure size, upper eyelid drop late exophthalmos eye movement and so on every 4 weeks and foUow-up for one year. Results Group A and group B of exophthalmos and eye movement improved obviously,however,Group C with poor efficacy and more side effects,and Group A in 3 groups was the fastest with least number of injections and which improved eye symptom significantly with fewer complications. Conclusion Orbital injection of triamcinolone combined with dexamethasone could be more rapid and effective than a simple injection of triamcinolone or oral prednisone to improve symptoms and signs in thyroid ophthalmopathy.

关 键 词：GRAVES眼病 曲安奈德 地塞米松 

分 类 号：R77[医药卫生—眼科] R5[医药卫生—临床医学]