高危型乳头瘤病毒感染与宫颈瘤样病变相关性探讨  

Exploration on the correlation between high-risk papillomavirus infection and CIN

作　　者：陆少颜[1] 伍淑瑶[1] 梁小萍[1] 陈泳言[1] 谭忠伟[1] 彭彧[1] 严秋林[1] 陈敏[1] 

机构地区：[1]广东省江门市妇幼保健院,529000

出　　处：《中国妇幼保健》2011年第21期3303-3304,共2页Maternal and Child Health Care of China

基　　金：2009年江门市科技局第四批科技计划项目〔江科(2009)76号〕

摘　　要：目的:探讨江门地区高危型人乳头瘤病毒(HPV)感染与宫颈瘤样病变(CIN)的相关性,以提高宫颈癌的诊断率。方法:2009年1月～2010年3月对宫颈异常的女性患者进行高危型HPV检测及宫颈病理组织学检查。结果:宫颈柱状上皮外移中高危型HPV的检测率是18.2%,在宫颈异常组中的表达有统计学的意义(P<0.05);高危型HPV的检测率随宫颈上皮内瘤样病变程度增高而升高,各组间存在差异有统计学意义(P<0.01)。结论:高危型HPV的感染与CIN密切相关,高危型HPV的检测是早期诊断宫颈病变和宫颈癌一个主要筛查方法。Objective： To explore the correlation between high - risk human papillomavirus （HPV） infection and cervical intraepithelial neoplasia （CIN） in Jiangmen region, in order to increase the diagnostic rate of cervical cancer. Methods： The female patients with cervical abnormality received high risk HPV detection and cervical histopathological test from January 2009 to March 2010. Results： The detection rate of high risk HPV in cervical columnar epithelium offshoring was 18.2% , the expression had significant difference in cervical abnormality group （ P 〈 0. 05 ） ; the detection rate of high risk HPV increased with the increase of degree of CIN, there was significant difference among different groups （P 〈 0. 01 ） . Conclusion： High risk HPV infection is related to CIN closely, the detection of high - risk HPV is a main screening method for early diagnosis of cervical lesion and cervical cancer.

关 键 词：人乳头状瘤病毒 宫颈上皮内瘤样病变 相关性 

分 类 号：R737.33[医药卫生—肿瘤]