机构地区:[1]北京大学第三医院消化科,100191 [2]北京大学第六医院社会精神病学与行为医学研究室
出 处:《中华医学杂志》2011年第27期1886-1890,共5页National Medical Journal of China
基 金:国家高技术研究发展计划"863"计划专题
摘 要:目的通过人格及精神障碍评估问卷了解医院就诊肠易激综合征(IBS)患者精神障碍的共病状况。方法顺序纳入2008年11月至2010年3月北京大学第三医院消化科门诊就诊、符合罗马Ⅲ标准的IBS患者83例,由经过培训的人员通过人格诊断问卷4(PDQ-4)、复合型国际诊断交谈(CIDI)表进行人格障碍、躯体形式障碍及其他精神障碍诊断。结果83例IBS患者中男43例,女40例,年龄(38±14)岁。其中便秘型20例(24.1%)、腹泻型31例(37.3%)、混合型15例(18.1%)、未分型17例(20.5%)。(1)62例(74.7%)患者被检出1型或多型人格障碍,性别差异无统计学意义,其中以强迫和回避为特征的焦虑·抑制类(C组)人格障碍最多(58例,69.9%)。存在人格障碍者躯体形式障碍检出率为46.8%(29/62),高于无人格障碍者[19.0%(4/21),P=0.025]。(2)IBS患者的CIDI-3.0精神障碍终生患病率44.6%(37例),显著高于对照组,性别差异无统计学意义。焦虑与心境障碍是最多见的精神障碍共病类型,分别为21例(25.3%)和19例(22.9%)。物质滥用和依赖、间歇性暴发障碍分别检出9例(10.8%)和7例(8.4%)。腹泻型IBS患者精神障碍共病率最高(58.1%,18/31),但不同IBS亚组之间精神障碍检出率差异无统计学意义。(3)IBS患者中33例(39.8%)存在躯体形式障碍,性别差异无统计学意义。各亚组间躯体形式障碍检出率差异无统计学意义。焦虑障碍同时合并躯体形式障碍者为61.9%(13/21),显著高于无焦虑障碍者[32.3%(20/62),P=0.016]。结论综合医院消化科就诊的IBS患者精神障碍共病较为常见,尤其是焦虑障碍和心境障碍。存在人格偏离及焦虑障碍的IBS患者更容易出现躯体形式障碍,消化专业医师应对此有充分认识并予以恰当治�Objective To assess the prevalence of psychiatric comorbidities in patients referred for irritable bowel syndrome ( IBS ) with questionnaires for mental disorders. Methods A total of 83 IBS patients at our hospital were enrolled and assessed with the Personality Diagnostic Questionnaire for DSM-Ⅳ, version 4 (PDQ-4) and Composite International Diagnostic Interview, version 3.0 and 2.1 ( CIDI-3.0 & CIDI-2. 1 ) by trained interviewers. Such items as personality dysfunction, mental disorder and somatization disorder were examined. Results The male-female ratio was 1.08/1. Their mean age was (38 ±14) years old, Among them, 20 patients (24. 1%) were predominant, 15 (18. 1%) mixed and 17 (20.5%) constipation-predominant, 31 ( 37.3% ) diarrheaunclassified type. ( 1 ) Sixty-two ( 74. 7% ) patients scored positive for any personality dysfunction. There was no significant gender difference. The cluster C (anxious-fearful) personality disorder was most commonly found in IBS patients (n = 58, 69. 9% ). The prevalence of somatoform disorders plus personality dysfuntion was 46. 8% (29/62). It was significantly higher than those without personality dysfunction [ 19. 0% (4/21), P = 0. 0251. (2) Thirty-seven patients (44. 6% ) had a lifetime CIDI-3.0 diagnosis. It was significantly higher than that in the general population. There was no gender difference. Anxiety and mood disorders were the most common types of psychiatric comorbidities [ n = 21 (25.3%) and n = 19 (22. 9% ) respectively ]. The lifetime prevalence of alcohol or nicotine abuse and(or) dependence and intermittent explosive disorder were 10. 8% (n = 9) and 8. 4% (n = 7). Psychiatric comorbidities were most commonly found in diarrhea-predominant patients (58. 1% ). But there was no significant difference among the subgroups. (3) Thirty-three patients (39. 8% ) had somatoform disorders. Neither gender nor subgroup difference was observed. The IBS patients with anxiety d
关 键 词:肠易激综合征 精神障碍 共病现象 人格诊断问卷4(PDQ-4) 复合性国际 诊断交谈表(CIDI)
分 类 号:R749.2[医药卫生—神经病学与精神病学]
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