Stargardt病的频域相干光断层扫描图像分析  

Relationship between central visual acuity and retinal volume of macular fovea accessed by spectral domain optical coherence tomography in Stargardt disease

作　　者：张枝桥[1] 张承芬[1] 董方田[1] 陈有信[1] 于伟泓[1] 戴荣平[1] 郑霖[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院眼科,100730

出　　处：《中华眼科杂志》2011年第7期628-632,共5页Chinese Journal of Ophthalmology

摘　　要：目的应用频域相干光断层扫描（OCT）技术评价Stargardt病患者黄斑区视网膜容积与中心视力之间的关系。方法回顾性病例系列研究。收集10例（20只眼）Stargardt病的临床资料进行回顾性分析。所有患者均使用频域OCT分别测量黄斑中心凹区视网膜厚度、黄斑中心凹区光感受器细胞内外节缺失宽度、黄斑中心凹区直径3mm和1mm范围内的视网膜容积。运用线性回归分析法，比较最小分辨角对数（10gMAR）视力与黄斑中心凹区视网膜厚度、黄斑中心凹区光感受器细胞内外节（IS／OS）缺失宽度、黄斑中心凹区直径3mm和1mm范围内视网膜容积的关系。结果18只眼的logMAR视力为0．30～1．22，黄斑中心凹区光感受器细胞内外节缺失宽度为847～5306μm，黄斑中心凹区视网膜厚度为20～126μm，黄斑中心凹区直径3mm和1mm范围内的视网膜容积分别为1．06～1．76mm3、0．06～0．13mm3。logMAR视力与黄斑中心凹区光感受器细胞内外节缺失宽度呈正相关（r=0．695，P〈0．05），与黄斑中心凹区视网膜厚度呈负相关（r=-0．601，P〈0．05），与黄斑中心凹区直径3mm范围内的视网膜容积呈负相关（r=-0．725，P〈0．05），与黄斑中心凹区直径1mm范围内的视网膜容积无相关性（r=-0．364，P〉0．05）。结论频域OCT技术可以清晰观察Stargardt病患者各层视网膜结构，频域OCT检测获得的黄斑区视网膜容积与中心视力间存在一定的相关性。Objective To assess the relationship between central visual acuity and retinal volume of macular fovea in patients with Stargardt disease by spectral-domain optical coherence tomography （SD OCT）. Methods It was a retrospective case series study. Twenty eyes of 10 patients with Stargardt disease were investigated by three-dimensional spectral-domain optical coherence tomography. SD OCT images were obtained and retrospectively analyzed. The retinal volumes of macular fovea were measured by SD OCT, whose diameters were set as 3 mm and 1 mm separately （ volume 3 and volume 1 ）. The retinal thickness of macular fovea （macular thickness） and the width of IS/OS conjunction loss of macular fovea （ IS/OS loss） were also measured by SD OCT. We correlated the logMAR BCVA with IS/OS loss, macular thickness, volume 3 and volume 1 by linear regression analysis. Results LogMAR BCVA was from 0. 3 to 1. 22. IS/OS loss was from 847 μm to 5306 μm. Macular thickness was from 20μm to 126 p,m. Volume 3 and volume 1 was from 1.06 to 1.76 mm3 and 0. 06 to 0. 13 mm3. LogMAR BCVA correlated with the IS/OS loss （ r = 0. 695, P 〈 0. 05 ）, macular thickness （ r = - 0. 601, P 〈 0. 05 ）, and volume 3 （ r = -0. 725, P 〈 0. 05 ）. LogMAR BCVA did not correlate with volume 1 （ r = - 0. 364, P 〉 0. 05 ）. Conclusions SD OCT could demonstrate the retinal structure of Stargardt disease clearly. The retinal volume of maeular fovea accessed by SD OCT correlated with the visual acuity of Stargardt disease.

关 键 词：相干光断层扫描 黄斑 视网膜 

分 类 号：R774.1[医药卫生—眼科]