GKN、TFF蛋白与胃癌  

GKN,TFF Proteins and Gastric Cancer

作　　者：王钰虹[1] 陈洁[1] 陈旻湖[1] 

机构地区：[1]中山大学附属第一医院消化内科,510080

出　　处：《胃肠病学》2011年第6期373-375,共3页Chinese Journal of Gastroenterology

基　　金：2010年度国家自然科学基金(No.81072048);2008年度国家自然科学基金(No.30871145)资助;2010年度中山大学重大项目培育和新兴;交叉学科资助计划(No.10ykjc23);2009年度高校基本科研业务费中山大学青年教师培育项目(No.09ykpy22)

摘　　要：Gastrokine(GKN)和三叶因子家族(TFF)是在正常胃黏膜上皮细胞中大量特异性表达且结构和功能密切相关的两个蛋白家族。GKN蛋白具有调节胃黏膜上皮细胞增殖和凋亡、维持胃黏膜完整和促进受损黏膜修复的作用;TFF蛋白具有促进损伤黏膜修复以及影响细胞运动、黏附、凋亡等作用。两者在胃癌组织和细胞株中表达异常,可能在胃癌的发生中起重要作用,为胃癌特异性抑癌基因。本文就GKN、TFF蛋白与胃癌的关系作一综述。Gastrokine （GKN） and trefoil factor family （TFF） are two structurally and functionally close related protein families expressed abundantly and specifically in gastric mucosal epithelial cells. GKN protein regulates gastric mucosal epithelial cell proliferation and apoptosis, maintains gastric mueosal integrity and promotes mucosal healing after injury. TFF protein promotes gastric mueosal repairing after injury, affects the movement, adhesion and apoptosis of epithelial cells. Expressions of GKN and TFF are abnormal in gastric cancer tissues and cell lines, which suggest that both of them play important roles in the development of gastric cancer and may be the specific suppressor genes of gastric cancer. This article reviewed the relationshio between GKN. TFF proteins and zastric cancer.

关 键 词：Gastrokine 三叶因子家族 胃肿瘤 基因 肿瘤抑制 

分 类 号：R735.2[医药卫生—肿瘤]