抑郁症患者血清S100B蛋白及其分泌型糖基化终产物受体的研究  

The study on serum levels of S100B and esRAGE in patients with major depression

作　　者：杨孔军[1] 荣晗[1] 刘铁榜[1] 冯飞[1] 杨海晨[1] 彭江发[1] 位照国[1] 齐立国[1] 邓小敏[1] 

机构地区：[1]深圳市精神卫生研究所,深圳市康宁医院,深圳518020

出　　处：《中国神经精神疾病杂志》2011年第7期418-420,共3页Chinese Journal of Nervous and Mental Diseases

基　　金：广东省医学科研基金项目(编号:A2009602);深圳市科技计划项目(编号:200903127)

摘　　要：目的探讨首发和复发抑郁症患者血清S100B蛋白及其分泌型糖基化终产物受体(esRAGE)浓度的改变。方法采用酶联免疫方法检测34例抑郁症患者(首发15例,复发19例)和34名正常对照的血清S100B、esRAGE蛋白浓度,比较患者组和对照组间的差异;采用17项汉密尔顿抑郁量表(Hamilton Depression Rating Scale-17,HAMD-17)评定患者的症状,分析上述两个生化指标与症状之间的关系。结果总体患者组血清S100B浓度高于对照组[(0.57±0.04)ng/mL vs(0.38±0.12)ng/mL,P<0.01],esRAGE浓度低于对照组[(0.52±0.11)ng/mL vs(0.66±0.10)ng/mL,P<0.01];首发和复发患者组之间血清S100B浓度与esRAGE的差异均有统计学意义[(0.46±0.01)ng/mL vs(0.57±0.02)ng/mL,P<0.01;(0.44±0.02)ng/mL vs(0.53±0.10)ng/mL,P<0.01];与对照组相比,首发及复发患者组的血清S100B浓度均升高而esRAGE浓度均下降,差异均有统计学意义(P<0.01)。未见患者组的血清S100B、esRAGE浓度相关或二者与HAMD评分相关(P>0.05)。结论血浆S100B、es-RAGE可能在抑郁症的发病中起了一定的作用,复发患者神经胶质细胞分泌S100B能力可能更强。Objective To investigate the association of serum S100B and esRAGE protein levels with traits of major depression. Methods The serum S100B and esRAGE levels in 34 major depressive patients including 15 cases of first episode, 19 cases of recurrence in depression group and 34 healthy volunteers in control group were examined using enzyme linked immunosorbent assay （ ELSIA ）. Depression symptoms were assessed using the Hamilton Depression Rating Scale （HAMD） and the associations between serum S100B and esRAGE levels with traits of the disorder were analyzed in depression group. Results The serum S100B levels were significantly higher in depression group than in control group（0.57 ±0. 04 ng/ml VS 0.38 ±0. 12ng/ml, P 〈 0.01 ）, on the contrast, serum esRAGE levels was significantly lower in depression group than in control group[ （0.52 ± 0.11 ）ng/ml vs （0.66 ± 0.10）ng/ml,P 〈 0.01 ） ]. The serum S100B and esRAGE levels were significant different between first episode and recurring subgroups in depression group[ （0.46± 0.01 ）ng/ml vs （0.57 ±0.02） ng/ml, P 〈 0.01 ; （0.44±0.02 ） ng/ml vs （0.53±0.10） ng/ml, P 〈 0.01 ） J. Compared with controls, both first episode and recurring patients had significantly higher levels of S100B and lower levels of esRAGE （ P 〈 0.01 ）. Serum SI00B levels were not correlated with esRAGE levels （P 〉 0.05）. Serum S100B and esRAGE levels were not correlated with HAMD scores in depression group （P 〉 0.05）. Conclusions Serum S100B and esRAGE levels may be a biomarker for major depression. Serum S100B and esRAGE levels are lower in first episode subgroups than in recurring subgroups, which suggest that Serum S100B and esRAGE levels may increase with the number of episode.

关 键 词：抑郁症 S100B蛋白 ESRAGE 病例对照研究 

分 类 号：R749.4[医药卫生—神经病学与精神病学]