儿童及青少年非酒精性脂肪性肝病的确诊及危险因素评估  

The diagnosis and risk factors for evaluation of nonalcoholic fatty liver disease in children and adolescents

作　　者：张一宁[1] 杜红伟[1] 刘彦军[2] 王朝霞[1] 

机构地区：[1]吉林大学第一医院小儿内分泌遗传代谢科,长春130021 [2]美国加州大学查尔斯医学院内分泌实验室

出　　处：《临床肝胆病杂志》2011年第7期690-693,共4页Journal of Clinical Hepatology

摘　　要：儿童和青少年时期非酒精性脂肪性肝病(NAFLD)是以肝细胞脂肪变性和脂肪蓄积为病理特征,而无饮酒史的临床综合征,它是代谢综合征和胰岛素抵抗在肝脏的表现,与儿童期的肥胖、性别、胰岛素抵抗和青春期具有相关性。因此,本病在儿童和青少年时期的诊断和评估要充分考虑不同于成人的许多高发风险因素,如性别、青春期的发育等因素。Non-alcoholic fatty liver disease （NAFLD） in children and adolescents is considered to be a syndrome that is histologically characterized by hepatic steatosis and the accumulation of large droplets of triglycerides within hepatocytes in the absence of chronic alcohol consumption. NAFLD is a representation of the metabolic syndrome and insulin resistance in the liver. In children, NAFLD has been consistently associated with obesity, gender, insulin resistance and puberty. Thus, the diagnosis and risk factors for evaluation of NAFLD in children and adolescents need strong consideration of multiple risk factors such as gender and pubertal development etc different from adults.

关 键 词：脂肪肝 危险因素 肥胖症 

分 类 号：R575.5[医药卫生—消化系统]