膜联蛋白A2过表达在肝细胞癌发生发展中的作用  

The role of annexin A2 overexpression in the development and progression of hepatocellular carcinoma

作　　者：张海健[1] 姚登福[1] 秦呈林[1] 

机构地区：[1]南通大学附属医院临床医学研究中心,江苏南通226001

出　　处：《临床肝胆病杂志》2011年第7期772-774,778,共4页Journal of Clinical Hepatology

基　　金：江苏省自然科学基金资助(BK2008187)

摘　　要：膜联蛋白A2与S100A10组装成异四聚体转位细胞膜从而激活相关信号通路或者Ser25磷酸化以后进入细胞核参与DNA合成和细胞增殖,可调节血管形成、与肝细胞癌(HCC)形成与预后相关。本文综述了膜联蛋白A2的分子构成、功能及对HCC诊断和预后价值的研究进展。Annexin A2 can translocate to the outer membrane surface and activate correlative signaling pathway through assembling heterotetramer with S100A10, and can enter nucleus and participate in DNA synthesis and cell proliferation after its Set^25 is phosphorylated. It regulates angiogenesis, involves formation of hepatocellular carcinoma （HCC）, and affects the prognosis of HCC. This review summarizes recent studies of its molecular constitution, function and the values of diagnosis and prognosis for HCC.

关 键 词：癌 肝细胞 膜联蛋白A2 

分 类 号：R735.7[医药卫生—肿瘤]