垂体腺瘤患者血清IL-6、TNF-α水平和细胞免疫的变化  

The Levels of IL-6,TNF-α in Sera and Cellular Immunity of Patients with Pituitary Tumor

作　　者：何旦莎[1] 曾白云[1] 邓维意[1] 蔡昭明[1] 

机构地区：[1]广州医学院神经科学研究所,广州510182

出　　处：《中国神经免疫学和神经病学杂志》1999年第4期209-212,共4页Chinese Journal of Neuroimmunology and Neurology

基　　金：广东省卫生厅医药卫生基金

摘　　要：目的　观察不同类型垂体腺瘤患者血清ＩＬ－６、ＴＮＦ－α水平，ＮＫ细胞活性和淋巴细胞亚型的变化。方法　根据垂体激素水平将３２例垂体腺瘤患者分为非分泌性垂体腺瘤和分泌性垂体腺瘤两组。用酶联免疫吸附法检测血清ＩＬ－６、ＴＮＦ－α浓度，３Ｈ－ＴｄＲ掺入法检测ＮＫ细胞活性，ＡＰＡＡＰ桥联酶标法进行淋巴细胞亚群分型。结果　各种类型垂体腺瘤血清ＩＬ－６、ＴＮＦ－α水平无明显变化，分泌催乳素（ＰＲＬ）腺瘤患者ＣＤ３＋ 、ＣＤ４＋ 细胞亚群比例明显低于正常对照组（Ｐ＜ ０．０５），分泌ＡＣＴＨ腺瘤患者ＮＫ细胞活性降低，Ｔ４细胞亚群减少，而非分泌性腺瘤患者细胞免疫功能无明显异常。结论　垂体腺瘤患者内分泌异常可干扰其细胞免疫功能。Objective\ To investigate IL 6,TNF α levels in sera, NK cell activity and subpopulation of T lymphocytes in patients with pituitary tumor(PT). Methods\ 32 cases of PT which were divided into non secreted PT group and secreted PT group according to the levels of the pituitary hormones. IL 6,TNF α levels in sera were determined by means of enzyme linkage immuno sorption assay, 3H TdR release assay was used to measure NK cell activity, and APAAP bridge enzyme label assay was used to type subpoppulation of T lymphocytes. Results\ The levels of IL 6,TNF α of patients with PT including secreted PT and non secreted PT were normal. The percentage of CD3 + and CD4 + cells were decreased in patients with secreted prolactin PT. Decrease in CD4 + cells an NK cell activity were observed in 3 cases of secreted adrenocorticotropic hormone PT compared with normal controls (P<0 05). Cellular immunity in patience with non secreted PT were not aberrant. Conclusion\ Endocrine disorders of patients with PT may disturb the cellular immunity function.

关 键 词：垂体腺瘤 神经内分泌 淋巴细胞 细胞因子 

分 类 号：R736.402[医药卫生—肿瘤]