19400例不育患者中罗伯逊易位携带者的临床分析  

Clinical analysis of Robertsonian translocation carrier in 19 400 infertile patients

作　　者：张清健[1] 郑立新[1] 田佩玲[1] 叶嘉玲[1] 杨卫[1] 王柏贤[1] 徐珊珊[1] 周冰燚[1] 戴朝霞[1] 蔡慧娜[1] 方俊宇[1] 朱志勇[1] 

机构地区：[1]广东省计划生育科学技术研究所,广州510600

出　　处：《中国男科学杂志》2011年第4期11-13,共3页Chinese Journal of Andrology

摘　　要：目的探讨不育人群中罗伯逊易位患者的核型分布特征及临床表现。方法采用外周血淋巴细胞培养，常规制备染色体，应用G显带技术进行核型分析。结果不育患者中罗伯逊易位发生率为O．23％，其中男性不育患者中罗伯逊易位发生率为0．29％，稍高于女性0．17％的发生率；以rob（13；14）最多30例，其次为rob（14；21）7例。结论罗伯逊易位可能是造成男性少精子、畸精子和无精子及女性不良妊娠史的重要原因之一。Objective To analyze the distribution characteristics and clinical manifestations of Robertsonian translocation carriers in infertile patients. Methods Chromosome specimens were made using routine culture of peripheral blood lymphocytes. Karyotyping analysis was mainly conducted by G banding. Results The incidence of Robertsonian translocation in infertile patients accounted for 0.23%, including 30 cases of rob （13; 14） and 7 cases of rob （14; 21）. The Incidence of Robertsonian translocation in infertile men （0.29%） was higher than that in infertile women （0.17%）. Conclusion Robertsonian translocation might be one of the important reasons for occurrence of male oligozoospermia, teratozoospermia or azoospermia, and female abnormal pregnancy.

关 键 词：不育 易位 遗传 核型分析 

分 类 号：R698.2[医药卫生—泌尿科学]