甲地孕酮减少化疗不良反应的临床观察  

Clinical observation of megestrol acetate in preventing adverse effects from chemotherapy

作　　者：杨武[1] 张振华[1] 朱西平[1] 

机构地区：[1]宁国市人民医院肿瘤科,安徽宁国242300

出　　处：《皖南医学院学报》2011年第4期288-290,共3页Journal of Wannan Medical College

摘　　要：目的:评估甲地孕酮减少化疗不良反应的疗效。方法:80例患者随机分成观察组(40例)和对照组(40例)。观察组化疗前2 d给予甲地孕酮160 mg 2次/d,至化疗后3 d停用,对照组单纯化疗。观察两组患者消化道和骨髓抑制以及食欲、体重、血压和血糖等变化。结果:观察组恶心呕吐症状明显减轻,白细胞下降的发生率低,食欲、体重增加与对照组比较差异显著性。血压和血糖升高发生率低,两组无显著性差异,观察组阴道出血的发生率高,与对照组比较有显著性差异。结论:化疗前后应用甲地孕酮可有效减轻化疗不良反应,改善患者营养状态,提高患者化疗耐受性和依从性。Objective：To evaluate the efficacy of megestrol acetate in preventing the side effects induced by chemotherapy.Methods： Eighty patients were randomly grouped into trials and controls（n=40 for each group）.Patients in the trial group received medication of megestrol acetate at dose of 160 mg,twice a day,two days before till day 3 after chemotherapy,and the controls were given simple chemotherapy.Two groups were observed regarding the gastrointestinal response,extent of myelosuppression,appetite,changes of body weight,blood pressure（BP） and blood glucose（BG）.Results： Symptoms of nausea and vomiting were found greatly relieved,with lower incidence of leucopenia but with improved appetite and body weight gain,as compared with the control subjects.Whereas there was no significant difference in BP and BG between the two groups.Higher incidence of vaginal bleeding was found in the trail subjects,significantly different from the controls（P0.05）.Conclusion： Megestrol acetate can effectively keep the patients from adverse reactions to chemotherapy and improve the condition of nutrition and tolerance and compliance,if this agent is administered around the therapy.

关 键 词：甲地孕酮 不良反应 化学治疗 耐受性 

分 类 号：R730.53[医药卫生—肿瘤]